Oscillatory potentials in electroretinogram as an early marker of visual abnormalities in vitamin A deficiency

Kakiuchi,Dai; Uehara,Taisuke; Shiotani,Motohiro; Nakano‑Ito,Kyoko; Suganuma,Akiyoshi; Aoki,Toyohiko; Tsukidate,Kazuo; Sawada,Kohei

doi:10.3892/mmr.2014.2852

Oscillatory potentials in electroretinogram as an early marker of visual abnormalities in vitamin A deficiency

Authors:
- Dai Kakiuchi
- Taisuke Uehara
- Motohiro Shiotani
- Kyoko Nakano‑Ito
- Akiyoshi Suganuma
- Toyohiko Aoki
- Kazuo Tsukidate
- Kohei Sawada
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Affiliations: Life Science Center of Tsukuba Advanced Research Alliance, Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305‑8577, Japan, Eisai Product Creation Systems, Eisai Co., Ltd., Tokodai, Tsukuba, Ibaraki 300‑2635, Japan
Published online on: November 3, 2014 https://doi.org/10.3892/mmr.2014.2852
Pages: 995-1003

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Abstract

Vitamin A deficiency (VAD) caused by malnutrition and certain intestinal diseases induces visual impairments, including night blindness and photoreceptor cell dysfunction as indicated by reduced a‑ and b‑waves in an electroretinogram (ERG). The effects of VAD on the inner retinal layer cells, including amacrine and ganglion cells, remain to be elucidated. The functions of these cells are reflected in oscillatory potentials (OPs), another component of the ERG. The present study investigated inner retinal layer cell function in VAD rats by analyzing OPs. In the present study, VAD was induced by feeding Brown Norway rats a vitamin A deficient diet for 10 weeks. A reduced body weight and peri‑papillary opacification indicative of papilledema without histopathological alterations were observed, which are considered early symptoms of VAD. At this stage, the ERG revealed reduced OPs as well as a‑ and b‑waves at various intensities of light stimulation. Further analysis indicated that the ratio of the alterations in OPs was more significant than those of a‑ and b‑waves. After 5 weeks of recovery, these changes returned to control levels. These results suggest that OPs are the most sensitive and early marker of VAD‑associated visual impairment in the ERG.

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1	Dowling JE and Wald G: Vitamin A deficiency and night blindness. Proc Natl Acad Sci USA. 44:648–661. 1958. View Article : Google Scholar : PubMed/NCBI
2	McLaren DS: Vitamin A deficiency disorders. J Indian Med Assoc. 97:320–323. 1999.
3	Lam Byron L: Nutritional, Toxic, and Pharmacological Effects. Electrophysiology of Vision: Clinical Testing and Applications. 1. 1st Edition. Taylor & Francis Group; Florida: pp. 407–435. 2005, View Article : Google Scholar
4	Dowling JE and Wald G: Nutritional night blindness. Ann NY Acad Sci. 74:256–265. 1959. View Article : Google Scholar : PubMed/NCBI
5	Lam Byron L: Full-Field Electroretinogram. Electrophysiology of Vision. Clinical Testing and Applications. 1. 1st Edition. Taylor & Francis Group; Florida: pp. 1–47. 2005, View Article : Google Scholar
6	Kawasaki K, Yonemura K, Yokogawa Y, Saito N and Kawakita S: Correlation between ERG oscillatory potential and psychophysical contrast sensitivity in diabetes. Doc Ophthalmol. 64:209–215. 1986. View Article : Google Scholar : PubMed/NCBI
7	Leguire LE, Pappa KS, Kachmer ML, Rogers GL and Bremer DL: Loss of contrast sensitivity in cystic fibrosis. Am J Ophthalmol. 111:427–429. 1991. View Article : Google Scholar : PubMed/NCBI
8	Witkovsky P: Dopamine and retinal function. Doc Ophthalmol. 108:17–40. 2004. View Article : Google Scholar : PubMed/NCBI
9	Jaffe MJ, Bruno G, Campbell G, Lavine RA, Karson CN and Weinberger DR: Ganzfeld electroretinographic findings in parkinsonism: untreated patients and the effect of levodopa intravenous infusion. J Neurol Neurosurg Psychiatry. 50:847–852. 1987. View Article : Google Scholar : PubMed/NCBI
10	Samad TA, Krezel W, Chambon P and Borrelli E: Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid × receptor family. Proc Natl Acad Sci USA. 94:14349–14354. 1997. View Article : Google Scholar
11	Wang HF and Liu FC: Regulation of multiple dopamine signal transduction molecules by retinoids in the developing striatum. Neuroscience. 134:97–105. 2005. View Article : Google Scholar : PubMed/NCBI
12	Bremner JD and McCaffery P: The neurobiology of retinoic acid in affective disorders. Prog Neuropsychopharmacol Biol Psychiatry. 32:315–331. 2008. View Article : Google Scholar
13	Veruki ML and Wässle H: Immunohistochemical localization of dopamine D1 receptors in rat retina. Eur J Neurosci. 8:2286–2297. 1996. View Article : Google Scholar : PubMed/NCBI
14	Veruki ML: Dopaminergic neurons in the rat retina express dopamine D2/3 receptors. Eur J Neurosci. 9:1096–1100. 1997. View Article : Google Scholar : PubMed/NCBI
15	Nguyen-Legros J, Versaux-Botteri C and Vernier P: Dopamine receptor localization in the mammalian retina. Mol Neurobiol. 19:181–204. 1999. View Article : Google Scholar : PubMed/NCBI
16	Wachtmeister L: Oscillatory potentials in the retina: what do they reveal. Prog Retin Eye Res. 17:485–521. 1998. View Article : Google Scholar : PubMed/NCBI
17	Gelatt Kirk N: Ophthalmic Examination and Diagnostics. Veterinary Ophthalmology. 2. 4th edition. Oxfordshire Blackwell Publishing; Oxford, UK: pp. 484–535. 2007
18	Fischer AJ, Wallman J, Mertz JR and Stell WK: Localization of retinoid binding proteins, retinoid receptors, and retinaldehyde dehydrogenase in the chick eye. J Neurocytol. 28:597–609. 1999. View Article : Google Scholar
19	Mori M, Ghyselinck NB, Chambon P and Mark M: Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. Invest Ophthalmol Vis Sci. 42:1312–1318. 2001.PubMed/NCBI
20	Marmor MF, Fulton AB, Holder GE, Miyake Y, Brigell M and Bach M; International Society for Clinical Electrophysiology of Vision. ISCEV standard for full-field clinical electroretinography (2008 update). Doc Ophthalmol. 118:69–77. 2009. View Article : Google Scholar
21	Yamashita H, Yamada-Nakayama C, Sugihara K, et al: Functional and morphological effects of β-estradiol in eyes with N-methyl-D-Aspartate-induced retinal neurotoxicity in rats. Exp Eye Res. 93:75–81. 2011. View Article : Google Scholar : PubMed/NCBI
22	Matsumoto A, Okada Y, Nakamichi M, et al: Disease progression of human SOD1 (G93A) transgenic ALS model rats. J Neurosci Res. 83:119–133. 2006. View Article : Google Scholar
23	Katz ML, Chen DM, Stientjes HJ and Stark WS: Photoreceptor recovery in retinoid-deprived rats after vitamin A replenishment. Exp Eye Res. 56:671–682. 1993. View Article : Google Scholar : PubMed/NCBI
24	Gelatt Kirk N: Ocular Manifestations of Systemic Diseases. Veterinary Ophthalmology. 2. 4th edition. Oxfordshire Blackwell Publishing; Oxford, UK: pp. 1617–1643. 2007
25	Scott CJ, Kardon RH, Lee AG, Frisén L and Wall M: Diagnosis and grading of papilledema in patients with raised intracranial pressure using optical coherence tomography vs clinical expert assessment using a clinical staging scale. Arch Ophthalmol. 128:705–711. 2010. View Article : Google Scholar : PubMed/NCBI
26	Wachtmeister L: Further studies of the chemical sensitivity of the oscillatory potentials of the electroretinogram (ERG) I. GABA- and glycine antagonists. Acta Ophthalmol (Copenh). 58:712–725. 1980. View Article : Google Scholar
27	Bondioni S, Angioni AR, Corbetta S, et al: Effect of 9-cis retinoic acid on dopamine D2 receptor expression in pituitary adenoma cells. Exp Biol Med (Maywood). 233:439–446. 2008. View Article : Google Scholar
28	Romert A, Tuvendal P, Simon A, Dencker L and Eriksson U: The identification of a 9-cis retinol dehydrogenase in the mouse embryo reveals a pathway for synthesis of 9-cis retinoic acid. Proc Natl Acad Sci USA. 95:4404–4409. 1998. View Article : Google Scholar : PubMed/NCBI
29	Krezel W, Ghyselinck N, Samad TA, et al: Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science. 279:863–867. 1998. View Article : Google Scholar : PubMed/NCBI
30	Bain G, Ramkumar TP, Cheng JM and Gottlieb DI: Expression of the genes coding for glutamic acid decarboxylase in pluripotent cell lines. Brain Res Mol Brain Res. 17:23–30. 1993. View Article : Google Scholar : PubMed/NCBI