Capsinoids suppress fat accumulation via lipid metabolism

Hong,Qin; Xia,Chen; Xiangying,Hu; Quan,Yuan

doi:10.3892/mmr.2014.2996

Capsinoids suppress fat accumulation via lipid metabolism

Authors:
- Qin Hong
- Chen Xia
- Hu Xiangying
- Yuan Quan
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Affiliations: Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: November 24, 2014 https://doi.org/10.3892/mmr.2014.2996
Pages: 1669-1674
Copyright: © Hong et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Capsaicin, found in red peppers, has been reported to have anti‑obesity, anti‑hypertension, anti‑diabetes and anti‑inflammatory functions. In the present study, we determined the effect of non‑pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice. Liver, the main tissue of lipid metabolism, was treated by capsinoids, and HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4 were found to be increased significantly, which demonstrated promotion of the lipid metabolism in liver and adipose tissues. In addition, by adding capsinoids, the induced adipocytes also demonstrated significantly increased levels of HMG‑CoA reductase, CPT‑1, FAT/CD36 and GLUT4. Oil red O staining also demonstrated that capsinoids decreased fat accumulation in the adipocytes. In conclusion, these results indicate that capsinoids may be worth investigating as a potential cure for obesity.

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