Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia

  • Authors:
    • Chenjiao Yao
    • Wei Du
    • Haibiug Chen
    • Sheng Xiao
    • Lihua Huang
    • Fang-Ping Chen
  • View Affiliations

  • Published online on: January 30, 2015     https://doi.org/10.3892/mmr.2015.3288
  • Pages: 4605-4610
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Abstract

The Fanconi anemia (FA)‑associated proteins FANCF and FANCD2 are important components of the FA pathway of DNA crosslink repair. FANCF and FANCD2 have been found to be involved in drug‑resistant multiple myeloma, ovarian cancer, non‑small‑cell lung cancer, and head and neck cancer. However, it is unclear whether these two genes participate in adriamycin (ADR)‑resistant leukemia. Therefore, the aim of the current study was to investigate FANCF and FANCD2 expression in drug‑resistant and drug‑sensitive leukemia cells. Western blot analysis revealed enhanced FANCF expression and monoubiquitination of FANCD2 in ADR‑resistant cells. Additionally, it was observed that drug‑resistant cells had reduced DNA damage compared with drug‑sensitive cells. The results of this study indicate that the FA pathway may confer leukemia resistance to ADR via enhanced DNA interstrand crosslink repair.
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June-2015
Volume 11 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yao C, Du W, Chen H, Xiao S, Huang L and Chen F: Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia. Mol Med Rep 11: 4605-4610, 2015
APA
Yao, C., Du, W., Chen, H., Xiao, S., Huang, L., & Chen, F. (2015). Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia. Molecular Medicine Reports, 11, 4605-4610. https://doi.org/10.3892/mmr.2015.3288
MLA
Yao, C., Du, W., Chen, H., Xiao, S., Huang, L., Chen, F."Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia". Molecular Medicine Reports 11.6 (2015): 4605-4610.
Chicago
Yao, C., Du, W., Chen, H., Xiao, S., Huang, L., Chen, F."Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia". Molecular Medicine Reports 11, no. 6 (2015): 4605-4610. https://doi.org/10.3892/mmr.2015.3288