Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)

  • Authors:
    • Xiaoyan Fu
    • Mingxing Ding
    • Ning Zhang
    • Jicheng Li
  • View Affiliations

  • Published online on: March 5, 2015     https://doi.org/10.3892/mmr.2015.3440
  • Pages: 13-19
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The prevention and control of tuberculosis (TB) on a global scale has become increasingly important with the emergence of multidrug‑resistant TB. Mycobacterium tuberculosis phages have been identified as an important investigative tool. Phage genomes exhibit a significant level of diversity and mosaic genome architecture, however, they are simple structures, which are amenable to genetic manipulation. Based on these characteristics, the phages may be used to construct a shuttle plasmid, which is an indispensable tool in the investigation of TB. Furthermore, they may be used for rapid diagnosis and assessing drug susceptibility of TB, including phage amplified assessment and reporter phage technology. With an improved understanding of mycobacteriophages, further clarification of the pathogenesis of TB, and of the implications for its diagnosis and therapy, may be elucidated.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Fu X, Ding M, Zhang N and Li J: Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Mol Med Rep 12: 13-19, 2015
APA
Fu, X., Ding, M., Zhang, N., & Li, J. (2015). Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review). Molecular Medicine Reports, 12, 13-19. https://doi.org/10.3892/mmr.2015.3440
MLA
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12.1 (2015): 13-19.
Chicago
Fu, X., Ding, M., Zhang, N., Li, J."Mycobacteriophages: An important tool for the diagnosis of Mycobacterium tuberculosis (Review)". Molecular Medicine Reports 12, no. 1 (2015): 13-19. https://doi.org/10.3892/mmr.2015.3440