search button

Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥40 years of age)

  • Authors:
    • Ajda Coker‑Gurkan
    • Deniz Coskun
    • Elif Damla Arisan
    • Pinar Obakan
    • Özer Soylu
    • Narcin Palavan Unsal

  • View Affiliations

  • Published online on: March 20, 2015     https://doi.org/10.3892/mmr.2015.3521
  • Pages: 1356-1362
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Inflammation and genetics have key roles in the pathogenesis of atherosclerosis, and the etiology of myocardial infarction (MI). Recent studies have indicated that lower serum levels of fetuin‑A may accelerate the vascular mineralization process, which leads to pathophysiological conditions, such as coronary heart disease and chronic renal failure. The aim of the present study was to evaluate the association between specific fetuin‑A polymorphisms (742 and 766) that are associated with circulating serum levels, and MI cases. The study consisted of 292 participants; 146 healthy control subjects and 146 patients with MI. The patient group was divided into two subgroups: 56 MI≤40 years and 90 MI≥40 years. The genotype distribution of fetuin 742 (C/T) and fetuin 766 (C/G) were determined by restriction enzyme digestion of polymerase chain reaction products. A significant difference was determined between the patients with MI and the control subjects with regards to fetuin‑A 742 C/T gene polymorphism (P=0.028), regardless of age. Genotype distributions of fetuin‑A 742 (C/G, P=0.004) and 766 (C/T, P=0.017) were statistically different in the older patients with MI (MI≥40 years old), as compared with the healthy controls; however, there were no significant differences between the younger patients with MI and the controls, with regards to fetuin‑A 742 C/T (P=0.519) and 766 C/G (P=0.653) gene polymorphisms. In addition, an association was observed between the presence of fetuin‑A 742 T and 766 G alleles, and MI cases. The present study demonstrates that fetuin‑A 742 (C/T) and 766 (C/G) genotypes may be risk factors for MI in patients older than 40 years of age.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Coker‑Gurkan A, Coskun D, Arisan ED, Obakan P, Soylu Ö and Unsal NP: Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥40 years of age). Mol Med Rep 12: 1356-1362, 2015
APA
Coker‑Gurkan, A., Coskun, D., Arisan, E.D., Obakan, P., Soylu, Ö., & Unsal, N.P. (2015). Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥40 years of age). Molecular Medicine Reports, 12, 1356-1362. https://doi.org/10.3892/mmr.2015.3521
MLA
Coker‑Gurkan, A., Coskun, D., Arisan, E. D., Obakan, P., Soylu, Ö., Unsal, N. P."Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥40 years of age)". Molecular Medicine Reports 12.1 (2015): 1356-1362.
Chicago
Coker‑Gurkan, A., Coskun, D., Arisan, E. D., Obakan, P., Soylu, Ö., Unsal, N. P."Fetuin-A 742 (C/T) and 766 (C/G) polymorphic sites are associated with increased risk of myocardial infarction in older patients (≥40 years of age)". Molecular Medicine Reports 12, no. 1 (2015): 1356-1362. https://doi.org/10.3892/mmr.2015.3521