Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer

  • Authors:
    • Xiujun Han
    • Shibing Wang
    • Wenjing Zhou
    • Ying Li
    • Wen Lei
    • Weiguo Lv
  • View Affiliations

  • Published online on: February 16, 2015     https://doi.org/10.3892/mmr.2015.3355
  • Pages: 435-441
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Abstract

Oncolytic adenoviruses (OA) have been investigated as virotherapeutic agents for the treatment of cervical cancer and thus far results are promising. However, the cytotoxicity of the viruses requires improvement. The present study demonstrated that this can be achieved by combining ZD55‑TRAIL, an OA containing the tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) gene, with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). It was demonstrated that these agents act synergistically to kill HeLa cells by inducing G2 growth arrest and apoptosis. Notably, in a mouse xenograft model, ZD55‑TRAIL/SAHA combination inhibited tumor growth. At the molecular level, it was found that upregulation of IκBα and the p50 and p65 subunits of nuclear factor‑κB induced by ZD55‑TRAIL, can be abrogated by SAHA treatment. These data strongly suggested that ZD55‑TRAIL/SAHA co‑treatment may serve as an effective therapeutic strategy against cervical cancer.
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July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Han X, Wang S, Zhou W, Li Y, Lei W and Lv W: Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer. Mol Med Rep 12: 435-441, 2015
APA
Han, X., Wang, S., Zhou, W., Li, Y., Lei, W., & Lv, W. (2015). Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer. Molecular Medicine Reports, 12, 435-441. https://doi.org/10.3892/mmr.2015.3355
MLA
Han, X., Wang, S., Zhou, W., Li, Y., Lei, W., Lv, W."Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer". Molecular Medicine Reports 12.1 (2015): 435-441.
Chicago
Han, X., Wang, S., Zhou, W., Li, Y., Lei, W., Lv, W."Synergistic combination of histone deacetylase inhibitor suberoylanilide hydroxamic acid and oncolytic adenovirus ZD55-TRAIL as a therapy against cervical cancer". Molecular Medicine Reports 12, no. 1 (2015): 435-441. https://doi.org/10.3892/mmr.2015.3355