Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p

  • Authors:
    • Da‑Wei Guo
    • Ya‑Xin Han
    • Lin Cong
    • Dong Liang
    • Guan‑Jun Tu
  • View Affiliations

  • Published online on: April 1, 2015     https://doi.org/10.3892/mmr.2015.3581
  • Pages: 2098-2106
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Osteoporosis is a disease characterized by loss of bone mass and degeneration of the microstructure of bone. Resveratrol (3,5,4‑tri‑hydroxystilbene; RESV) may delay the onset of a variety of age‑related diseases. In the present study, an ovariectomized female rat model was used to detect the changes in microRNAs (miRNAs/miRs) following RESV treatment. Subsequently, the target genes of miRNA were predicted using TargetScan software and determined using a dual‑luciferase reporter assay. Finally, the role of miR‑338‑3p in the proliferation and differentiation of human osteoblast (HOB) cells was confirmed. The predominant finding of the present study was the identification of an intact mechanism of the effect of RESV in osteoporosis treatment. The results suggested that RESV suppresses miR‑338‑3p, followed by an increase in the expression of runt‑related transcription factor 2 in HOB cells.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo DW, Han YX, Cong L, Liang D and Tu GJ: Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Mol Med Rep 12: 2098-2106, 2015
APA
Guo, D., Han, Y., Cong, L., Liang, D., & Tu, G. (2015). Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p. Molecular Medicine Reports, 12, 2098-2106. https://doi.org/10.3892/mmr.2015.3581
MLA
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12.2 (2015): 2098-2106.
Chicago
Guo, D., Han, Y., Cong, L., Liang, D., Tu, G."Resveratrol prevents osteoporosis in ovariectomized rats by regulating microRNA-338-3p". Molecular Medicine Reports 12, no. 2 (2015): 2098-2106. https://doi.org/10.3892/mmr.2015.3581