Homozygosity analysis in subjects with autistic spectrum disorder

  • Authors:
    • Ahmad Adi
    • Basma Tawil
    • Mohammed Aldosari
    • Jameela Shinwari
    • Michael Nester
    • Hisham Aldhalaan
    • Hussain Alshamrani
    • Manar Ghannam
    • Brian Meyer
    • Nada Al Tassan
  • View Affiliations

  • Published online on: April 22, 2015     https://doi.org/10.3892/mmr.2015.3663
  • Pages: 2307-2312
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Abstract

Autistic spectrum disorder (ASD) is a complex neurodevelopmental disorder that results in social and communication impairments, as well as repetitive and stereotyped patterns. Genetically, ASD has been described as a multifactorial genetic disorder. The aim of the present study was to investigate possible susceptibility loci of ASD, utilizing the highly consanguineous and inbred nature of numerous families within the population of Saudi Arabia. A total of 13 multiplex families and 27 affected individuals were recruited and analyzed using Affymetrix GeneChip® Mapping 250K and 6.0 arrays as well as Axiom arrays. Numerous regions of homozygosity were identified, including regions in genes associated with synaptic function and neurotransmitters, as well as energy and mitochondria‑associated genes, and developmentally‑associated genes. The loci identified in the present study represent regions that may be further investigated, which could reveal novel changes and variations associated with ASD, reinforcing the complex inheritance of the disease.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Adi A, Tawil B, Aldosari M, Shinwari J, Nester M, Aldhalaan H, Alshamrani H, Ghannam M, Meyer B, Al Tassan N, Al Tassan N, et al: Homozygosity analysis in subjects with autistic spectrum disorder. Mol Med Rep 12: 2307-2312, 2015
APA
Adi, A., Tawil, B., Aldosari, M., Shinwari, J., Nester, M., Aldhalaan, H. ... Al Tassan, N. (2015). Homozygosity analysis in subjects with autistic spectrum disorder. Molecular Medicine Reports, 12, 2307-2312. https://doi.org/10.3892/mmr.2015.3663
MLA
Adi, A., Tawil, B., Aldosari, M., Shinwari, J., Nester, M., Aldhalaan, H., Alshamrani, H., Ghannam, M., Meyer, B., Al Tassan, N."Homozygosity analysis in subjects with autistic spectrum disorder". Molecular Medicine Reports 12.2 (2015): 2307-2312.
Chicago
Adi, A., Tawil, B., Aldosari, M., Shinwari, J., Nester, M., Aldhalaan, H., Alshamrani, H., Ghannam, M., Meyer, B., Al Tassan, N."Homozygosity analysis in subjects with autistic spectrum disorder". Molecular Medicine Reports 12, no. 2 (2015): 2307-2312. https://doi.org/10.3892/mmr.2015.3663