MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1

Sun,Ji‑Yong; Xiao,Wei‑Zhong; Wang,Fei; Wang,Yong‑Qian; Zhu,You‑Hou; Wu,Yi‑Fang; Miao,Zeng‑Li; Lin,Yu‑Chang

doi:10.3892/mmr.2015.3657

MicroRNA-320 inhibits cell proliferation in glioma by targeting E2F1

Authors:
- Ji‑Yong Sun
- Wei‑Zhong Xiao
- Fei Wang
- Yong‑Qian Wang
- You‑Hou Zhu
- Yi‑Fang Wu
- Zeng‑Li Miao
- Yu‑Chang Lin
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Affiliations: Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214002, P.R. China, Department of Neurology, Shanghai Pudong Hospital, Fudan University, Pudong, Shanghai 201399, P.R. China, Department of Neurosurgery, Tongji Hospital, Tongji University, Shanghai 200065, P.R. China, Department of Neurosurgery, Longhua Hospital Affiliated Shanghai Traditional Chinese Medical University, Shanghai 200032, P.R. China
Published online on: April 22, 2015 https://doi.org/10.3892/mmr.2015.3657
Pages: 2355-2359

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Abstract

MicroRNAs (miRs) are a class of small non-coding RNAs that are involved in the regulation of gene expression, and in cancer development and progression. In the present study, miR‑320 expression was found to be significantly reduced in glioma tissue in comparison with that in adjacent healthy tissues. In the present study, in vitro analyses demonstrated that overexpression of miR‑320 inhibited cell proliferation and metastasis, while antisense miR‑320 oligonucleotides enhanced cell proliferation and migration in U251 and SHG‑44 glioma cell lines, compared with that in negative control cells. Protein expression of E2F1, a cell‑cycle regulator, was negatively regulated by miR‑320. Therefore, the present study provides novel insights into the association between miR-320 and glioma development.

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