Open Access

Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor

  • Authors:
    • Rui Huang
    • Guiyu Wang
    • Yanni Song
    • Qingchao Tang
    • Qi You
    • Zheng Liu
    • Yinggang Chen
    • Qian Zhang
    • Jiaying Li
    • Shan Muhammand
    • Xishan Wang
  • View Affiliations

  • Published online on: April 28, 2015     https://doi.org/10.3892/mmr.2015.3694
  • Pages: 2417-2424
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Colorectal cancer stem cells (Co-CSCs) are a small subpopulation of tumor cells which have been proposed to be tumor‑initiating cells in colorectal cancer (CRC) and to be implicated in resistance to standard chemotherapy. Chemoresistance is a common problem in the clinic. However, the interrelation between Co‑CSCs and chemoresistant cells has yet to be elucidated. The present study investigated the Co‑CSC phenotype in colonospheres and chemoresistant CRC cell lines and aimed to identify targets for therapy. Colonospheres and chemoresistant CRC cells were found to be enriched with the CSC markers CD133 and CD44, and exhibited similar phenotypes. Furthermore, it was found that Notch signaling may simultaneously regulate Co‑CSCs and chemoresistant cells and may represent a novel strategy for targeting this pathway in CRC.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang R, Wang G, Song Y, Tang Q, You Q, Liu Z, Chen Y, Zhang Q, Li J, Muhammand S, Muhammand S, et al: Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Mol Med Rep 12: 2417-2424, 2015
APA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z. ... Wang, X. (2015). Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Molecular Medicine Reports, 12, 2417-2424. https://doi.org/10.3892/mmr.2015.3694
MLA
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12.2 (2015): 2417-2424.
Chicago
Huang, R., Wang, G., Song, Y., Tang, Q., You, Q., Liu, Z., Chen, Y., Zhang, Q., Li, J., Muhammand, S., Wang, X."Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor". Molecular Medicine Reports 12, no. 2 (2015): 2417-2424. https://doi.org/10.3892/mmr.2015.3694