Open Access

Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function

  • Authors:
    • Shao‑Lin Zeng
    • Li‑Hui Wang
    • Ping Li
    • Wei Wang
    • Jiong Yang
  • View Affiliations

  • Published online on: April 30, 2015     https://doi.org/10.3892/mmr.2015.3706
  • Pages: 2511-2520
  • Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Mesenchymal stem cells (MSCs) have been investigated in the treatment of numerous autoimmune diseases. However, the immune properties of MSCs on the development of asthma have remained to be fully elucidated. Airway dendritic cells (DCs) have an important role in the pathogenesis of allergic asthma, and disrupting their function may be a novel therapeutic approach. The present study used a mouse model of asthma to demonstrate that transplantation of MSCs suppressed features of asthma by targeting the function of lung myeloid DCs. MSCs suppressed the maturation and migration of lung DCs to the mediastinal lymph nodes, and thereby reducing the allergen‑specific T helper type 2 (Th2) response in the nodes. In addition, MSC‑treated DCs were less potent in activating naive and effector Th2 cells and the capacity of producing chemokine (C‑C motif) ligand 17 (CCL17) and CCL22, which are chemokines attracting Th2 cells, to the airways was reduced. These results supported that MSCs may be used as a potential treatment for asthma.
View Figures
View References

Related Articles

Journal Cover

August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zeng SL, Wang LH, Li P, Wang W and Yang J: Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12: 2511-2520, 2015
APA
Zeng, S., Wang, L., Li, P., Wang, W., & Yang, J. (2015). Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Molecular Medicine Reports, 12, 2511-2520. https://doi.org/10.3892/mmr.2015.3706
MLA
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12.2 (2015): 2511-2520.
Chicago
Zeng, S., Wang, L., Li, P., Wang, W., Yang, J."Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function". Molecular Medicine Reports 12, no. 2 (2015): 2511-2520. https://doi.org/10.3892/mmr.2015.3706