Open Access

Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein

  • Authors:
    • Yu Sen Hou
    • Ling Ying Liu
    • Jia Ke Chai
    • Yong Hui Yu
    • Hong Jie Duan
    • Quan Hu
    • Hui Nan Yin
    • Yi He Wang
    • Shu Bo Zhuang
    • Jun Fan
    • Wan Li Chu
    • Li Ma
  • View Affiliations

  • Published online on: May 4, 2015     https://doi.org/10.3892/mmr.2015.3723
  • Pages: 2521-2528
  • Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Mesenchymal stem cell (MSC)-based regenerative therapy is currently regarded as a novel approach with which to repair damaged tissues. However, the efficiency of MSC transplantation is limited due to the low survival rate of engrafted MSCs. Lipopolysaccharide (LPS) production is increased in numerous diseases and serves an essential function in the regulation of apoptosis in a variety of cell types. Previous studies have indicated that low‑dose LPS pretreatment contributes to cytoprotection. In the current study, LPS was demonstrated to induce apoptosis in human umbilical cord mesenchymal stem cells (hUCMSCs) via the activation of caspase, in a dose‑dependent manner. Low‑dose LPS pretreatment may protect hUCMSCs against apoptosis induced by high‑dose LPS, by upregulating the expression of cellular FADD‑like IL‑1β‑converting enzyme‑inhibitory protein (c‑FLIP). The results of the present study indicate that pretreatment with an appropriate concentration of LPS may alleviate high-dose LPS-induced apoptosis.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Hou YS, Liu LY, Chai JK, Yu YH, Duan HJ, Hu Q, Yin HN, Wang YH, Zhuang SB, Fan J, Fan J, et al: Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Mol Med Rep 12: 2521-2528, 2015
APA
Hou, Y.S., Liu, L.Y., Chai, J.K., Yu, Y.H., Duan, H.J., Hu, Q. ... Ma, L. (2015). Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein. Molecular Medicine Reports, 12, 2521-2528. https://doi.org/10.3892/mmr.2015.3723
MLA
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12.2 (2015): 2521-2528.
Chicago
Hou, Y. S., Liu, L. Y., Chai, J. K., Yu, Y. H., Duan, H. J., Hu, Q., Yin, H. N., Wang, Y. H., Zhuang, S. B., Fan, J., Chu, W. L., Ma, L."Lipopolysaccharide pretreatment inhibits LPS-induced human umbilical cord mesenchymal stem cell apoptosis via upregulating the expression of cellular FLICE-inhibitory protein". Molecular Medicine Reports 12, no. 2 (2015): 2521-2528. https://doi.org/10.3892/mmr.2015.3723