Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility

  • Authors:
    • Malgorzata Szczepańska
    • Adrianna Mostowska
    • Przemyslaw Wirstlein
    • Jana Skrzypczak
    • Matthew Misztal
    • Paweł P. Jagodziński
  • View Affiliations

  • Published online on: May 6, 2015     https://doi.org/10.3892/mmr.2015.3733
  • Pages: 3055-3060
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Abstract

Data suggests that dopamine receptor DRD2 gene variants may contribute to hyperprolactinemia and that they may be risk factors for endometriosis‑related infertility. The purpose of the present study was to determine whether nucleotide variants of the DRD2 gene may be associated with infertility related to endometriosis. Five DRD2 SNPs, rs1800497, rs6277, rs2283265, rs4245146 and rs4648317, which are located in different blocks of linkage disequilibrium, were studied in 151 cases and 381 controls. No significant differences between DRD2 rs1800497, rs6277, rs2283265, rs4245146 and rs4648317 genotype, allele nor haplotype frequencies were observed in women with endometriosis‑related infertility compared with the control group. The present results did not confirm DRD2 gene variants to be genetic risk factors for endometriosis-related infertility.
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August-2015
Volume 12 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Szczepańska M, Mostowska A, Wirstlein P, Skrzypczak J, Misztal M and Jagodziński PP: Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Mol Med Rep 12: 3055-3060, 2015
APA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., & Jagodziński, P.P. (2015). Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility. Molecular Medicine Reports, 12, 3055-3060. https://doi.org/10.3892/mmr.2015.3733
MLA
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12.2 (2015): 3055-3060.
Chicago
Szczepańska, M., Mostowska, A., Wirstlein, P., Skrzypczak, J., Misztal, M., Jagodziński, P. P."Polymorphic variants in the dopamine receptor D2 in women with endometriosis-related infertility". Molecular Medicine Reports 12, no. 2 (2015): 3055-3060. https://doi.org/10.3892/mmr.2015.3733