MicroRNA‑216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B

Li,Lei; Ma,Hui‑Qiang

doi:10.3892/mmr.2015.3761

MicroRNA‑216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B

Authors:
- Lei Li
- Hui‑Qiang Ma
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Affiliations: Department of Stomatology, Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China
Published online on: May 8, 2015 https://doi.org/10.3892/mmr.2015.3761
Pages: 3156-3162

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Abstract

There is increasing evidence to suggest that microRNAs (miRNAs; miRs) are involved in the development of oral squamous cell carcinoma (OSCC). miR‑216a has been identified as being involved in tumorigenesis, however, the mechanisms of miR‑216a in various types of cancer, either as a tumor suppressor or as an oncogenic miRNA, and the specific regulatory role of miR‑216a in OSCC remain to be elucidated. The present study demonstrated that the expression of miR‑216a was significantly reduced in OSCC tissues and cell lines. Overexpression of miR‑216a significantly suppressed the proliferation, colony formation, migration and invasion of the OSCC cells. In addition, eukaryotic translation initiation factor 4B (EIF4B) was identified as a direct target of miR‑216a, which was observed to be upregulated in the OSCC tissues. Furthermore, overexpression of EIF4B significantly attenuated the antitumor effect of miR‑216a, and a negative correlation was observed between miR‑216a and EIF4B in the OSCC tissues. Taken together, these findings indicated that miR‑216a has a suppressive role in OSCC cells by directly targeting EIF4B, and may function as a potential prognostic biomarker and novel therapeutic target.

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