Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice

Wang,Tao; Lim,Ji‑Na; Lee,Jae‑Sung; Lee,Sang‑Bum; Hwang,Jin‑Hee; Jung,U‑Suk; Kim,Min‑Jeong; Hwang,Dae‑Youn; Lee,Sang‑Rak; Roh,Sang‑Gun; Lee,Hong‑Gu

doi:10.3892/mmr.2015.3767

Effects of dietary trans‑9 octadecenoic acid, trans‑11 vaccenic acid and cis‑9, trans‑11 conjugated linoleic acid in mice

Authors:
- Tao Wang
- Ji‑Na Lim
- Jae‑Sung Lee
- Sang‑Bum Lee
- Jin‑Hee Hwang
- U‑Suk Jung
- Min‑Jeong Kim
- Dae‑Youn Hwang
- Sang‑Rak Lee
- Sang‑Gun Roh
- Hong‑Gu Lee
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Affiliations: Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China, Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 143‑701, Republic of Korea, Department of Biomaterials Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Gyeongnam 627‑706, Republic of Korea, Lab of Animal Physiology, Graduate School of Agriculture Science, Tohoku University, Sendai, Miyagi 988‑8555, Japan
Published online on: May 8, 2015 https://doi.org/10.3892/mmr.2015.3767
Pages: 3200-3206

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Abstract

The aim of the present study was to investigate the effects of dietary trans fatty acids in mice. Following the administration of a 0.5/100 g diet of trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) or cis‑9, trans‑11 conjugated linoleic acid (CLA) for 4 weeks, the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). The EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently. The potential effects of three well-known fatty acids, including trans‑9 octadecenoic acid (EA), trans‑11 vaccenic acid (TVA) and cis‑9, trans‑11 conjugated linoleic acid (CLA), in animals or humans remain to be elucidated. Therefore, in the present study, 32 animals were randomly divided into four groups and administered a 0.5/100 g diet of EA, TVA or CLA for 4 weeks. The results demonstrated that the body weights and the weights of the liver, testis and mediastinal adipose tissue (MAT) of the animals gradually decreased (P<0.05). Blood was collected individually via the external jugular veins and the EA group exhibited the lowest levels of magnesium and triglycerides (P<0.05). CLA increased villus length (P<0.05), while EA and TVA decreased villus length (P<0.05). The TVA group exhibited the lowest levels of low‑density lipoprotein and tumor necrosis factor‑α (P<0.05). Taken together, EA, TVA and CLA affected the physiological conditions of mice differently and these may further our understanding of the various effects of these fatty acids on animals and humans.

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