GSK1904529A, an insulin‑like growth factor‑1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration

Zhou,Qiang; Zhang,Junxia; Cui,Qinying; Li,Xiaodong; Gao,Ge; Wang,Yanfen; Xu,Yuping; Gao,Xiaoqun

doi:10.3892/mmr.2015.3869

GSK1904529A, an insulin‑like growth factor‑1 receptor inhibitor, inhibits glioma tumor growth, induces apoptosis and inhibits migration

Authors:
- Qiang Zhou
- Junxia Zhang
- Qinying Cui
- Xiaodong Li
- Ge Gao
- Yanfen Wang
- Yuping Xu
- Xiaoqun Gao
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Affiliations: Department of Pathology, Children's Hospital of Zhengzhou, Zhengzhou, Henan 450052, P.R. China, Department of Anatomy, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Ophthalmology, People's Hospital of Zhengzhou, Zhengzhou, Henan 450012, P.R. China, Department of Physiology, Basic Medical College, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Dermatology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China
Published online on: May 28, 2015 https://doi.org/10.3892/mmr.2015.3869
Pages: 3381-3385
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insulin‑like growth factor (IGF)/IGF‑1 receptor (IGF‑1R) signaling pathway regulates cell proliferation, motility and survival. The dysregulation of this signaling pathway has been implicated in the development of malignant gliomas. In the present study, GSK1904529A, a small molecule inhibitor of IGF‑1R, suppressed glioma cell viability, induced glioma cell apoptosis and inhibited glioma cell migration in vitro. In addition, GSK1904529A inhibited glioma tumor growth and induced tumor cell apoptosis in vivo. In conclusion, the results of the present study suggested GSK1904529A as a promising agent for the treatment of malignant glioma.

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