Effects of astaxanthin on dinitrofluorobenzene-induced contact dermatitis in mice

Kim,Hyungwoo; Ahn,Yong‑Tae; Lee,Guem  San; Cho,Su  In; Kim,Jong‑Myoung; Lee,Chu; Lim,Byung  Kwan; Ju,Seong‑A; An,Won  Gun

doi:10.3892/mmr.2015.3892

Effects of astaxanthin on dinitrofluorobenzene-induced contact dermatitis in mice

Authors:
- Hyungwoo Kim
- Yong‑Tae Ahn
- Guem San Lee
- Su In Cho
- Jong‑Myoung Kim
- Chu Lee
- Byung Kwan Lim
- Seong‑A Ju
- Won Gun An
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Affiliations: Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 626‑870, Republic of Korea, Department of Biomedical Science, Kyungdong University, Goseong-gun, Gangwon-do 219‑832, Republic of Korea, Oriental Medicine, Woosuk University, Jeonju 565‑701, Republic of Korea, Department of Marine Biomaterials and Aquaculture, Pukyong National University, Busan 608‑737, Republic of Korea, Aquaculture Industry Division, National Fisheries Research and Development Institute, Gangneung, Gangwon‑do 210‑861, Republic of Korea, Department of Visual Optics, Kyungdong University, Goseong-gun, Gangwon-do 219‑832, Republic of Korea, Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan 682‑714, Republic of Korea
Published online on: June 4, 2015 https://doi.org/10.3892/mmr.2015.3892
Pages: 3632-3638

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Abstract

Astaxanthin (AST) is known to exhibit antioxidative and antitumor properties, therefore, the present study investigated its other potential medical applications. AST was observed to exhibit anti‑allergic and anti‑inflammatory effects in a dinitrofluorobenzene (DNFB)‑induced contact dermatitis (CD) mouse model and RBL‑2H3 cell lines. The topical application of AST effectively inhibited the enlargement of ear thickness and increase in weight, which occurred following repeated application of DNFB. Furthermore, topical application of different concentrations of AST inhibited inflammatory hyperplasia, edema, spongiosis, and the infiltration of mononuclear cells and mast cells in the ear tissue. In addition, the levels of TNF‑α and IFN‑γ produced were decreased by application of AST in vivo, and treatment of RBL‑2H3 cells with AST inhibited the release of histamine and β‑hexosaminidase in vitro. Taken together, these data suggested that AST may be used to treat patients with allergic skin diseases through a mechanism, which may be associated with that involved in anti‑inflammatory or anti-allergic activities.

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