Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats

  • Authors:
    • Fan Pan
    • Naishun Liao
    • Youshi Zheng
    • Yingchao Wang
    • Yunzhen Gao
    • Sen Wang
    • Yi Jiang
    • Xiaolong Liu
  • View Affiliations

  • Published online on: May 26, 2015     https://doi.org/10.3892/mmr.2015.3847
  • Pages: 3725-3733
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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver injury affecting the general health of various populations. In the present study, adipose tissue‑derived stem cells (ADSCs), which were isolated from the adipose tissues of Sprague‑Dawley rats, were transplanted into the liver of high‑fat‑diet‑induced NAFLD rats via the portal vein to attenuate the disease progression of NAFLD. The results demonstrated that ADSC transplantation reduced the serum levels of alanine aminotransferase, total bilirubin, total cholesterol, triglycerides and fatty acids, and reduced the content of malondialdehyde in the liver homogenates. By contrast, ADSC transplantation caused a significant increase in superoxide dismutase activity. These data suggested that the ADSC transplantation improved the liver function, and reduced lipid metabolism and oxidative stress. In addition, the hepatic pathological changes were decelerated, lipid accumulation was reduced, and serum levels of the pro‑inflammatory factors, tumor necrosis factor‑α and interleukin‑6, were downregulated by the ADSC transplantation. Taken together, transplantation with ADSCs attenuates the disease progression of high‑fat‑diet induced NAFLD, therefore, may offer a potential therapeutic approach for the treatment of NAFLD.
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September-2015
Volume 12 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Pan F, Liao N, Zheng Y, Wang Y, Gao Y, Wang S, Jiang Y and Liu X: Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats. Mol Med Rep 12: 3725-3733, 2015
APA
Pan, F., Liao, N., Zheng, Y., Wang, Y., Gao, Y., Wang, S. ... Liu, X. (2015). Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats. Molecular Medicine Reports, 12, 3725-3733. https://doi.org/10.3892/mmr.2015.3847
MLA
Pan, F., Liao, N., Zheng, Y., Wang, Y., Gao, Y., Wang, S., Jiang, Y., Liu, X."Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats". Molecular Medicine Reports 12.3 (2015): 3725-3733.
Chicago
Pan, F., Liao, N., Zheng, Y., Wang, Y., Gao, Y., Wang, S., Jiang, Y., Liu, X."Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats". Molecular Medicine Reports 12, no. 3 (2015): 3725-3733. https://doi.org/10.3892/mmr.2015.3847