Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction

  • Authors:
    • Josefine Linke
    • Kirsten Utpatel
    • Carmen Wolke
    • Matthias Evert
    • Jens‑Peter Kühn
    • Alicja Bukowska
    • Andreas Goette
    • Uwe Lendeckel
    • Barbara Peters
  • View Affiliations

  • Published online on: July 13, 2015     https://doi.org/10.3892/mmr.2015.4077
  • Pages: 5169-5178
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Abstract

Dronedarone has been demonstrated to be harmful in patients with recent decompensated heart failure. Furthermore, a PALLAS study reported that dronedarone therapy increases mortality rates in patients with permanent atrial fibrillation. Although a pathophysiological explanation for these finding remains to be elucidated, the long term effects of dronedarone on myocardial structure and stability have been suggested. The aim of the present study was to determine whether dronedarone therapy affects left ventricular (LV) function in a chronic model of myocardial infarction (MI). An anterior MI was induced in 16 pigs. Of these animals, eight pigs were then treated with dronedarone for 1 week prior to, and 4 weeks following MI, the remaining pigs served as controls. LV angiography was performed 4 weeks after MI to determine the LV ejection fraction (LVEF). A post‑mortem magnetic resonance imaging scan of the LV was then performed on the two groups (n=6) to determine the volume and size of the induced MI. Dronedarone therapy did not affect systemic and intracardiac hemodynamic parameters or LVEF during the follow‑up assessment. Of note, dronedarone had no negative effect on the total infarct volume and size and did not induce lethal proarrhythmic effects following the induced anterior MI. Therefore, the results suggested that dronedarone did not increase the volume or size of induced anterior MI and did not affect LV performance. Thus, dronedarone therapy was observed to be safe in a porcine model of anterior MI.
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October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Linke J, Utpatel K, Wolke C, Evert M, Kühn JP, Bukowska A, Goette A, Lendeckel U and Peters B: Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction. Mol Med Rep 12: 5169-5178, 2015
APA
Linke, J., Utpatel, K., Wolke, C., Evert, M., Kühn, J., Bukowska, A. ... Peters, B. (2015). Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction. Molecular Medicine Reports, 12, 5169-5178. https://doi.org/10.3892/mmr.2015.4077
MLA
Linke, J., Utpatel, K., Wolke, C., Evert, M., Kühn, J., Bukowska, A., Goette, A., Lendeckel, U., Peters, B."Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction". Molecular Medicine Reports 12.4 (2015): 5169-5178.
Chicago
Linke, J., Utpatel, K., Wolke, C., Evert, M., Kühn, J., Bukowska, A., Goette, A., Lendeckel, U., Peters, B."Dronedarone does not affect infarct volume as assessed by magnetic resonance imaging in a porcine model of myocardial infarction". Molecular Medicine Reports 12, no. 4 (2015): 5169-5178. https://doi.org/10.3892/mmr.2015.4077