Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis

  • Authors:
    • Hongbin Jiang
    • Jun Zhang
    • Zhemin Zhang
    • Shengxiang Ren
    • Chuansen Zhang
  • View Affiliations

  • Published online on: August 5, 2015     https://doi.org/10.3892/mmr.2015.4178
  • Pages: 5933-5938
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Abstract

Stem cell‑based cell therapy has provided a promising method for the treatment of pulmonary diseases, including idiopathic pulmonary fibrosis (IPF). Furthermore, adipose‑derived stem cells (ADSCs) have been reported to be effective in lung repair and regeneration. In the current study, IPF was induced in mice by intratracheal instillation of bleomycin (BLM), and ADSCs were delivered systemically into the mice via the tail vein to evaluate the effects of ADSC transplantation. The ADSC engraftment rate and morphometric changes in lung tissue samples in vivo were investigated by histochemistry and immunohistochemistry, as well as by western blotting. The results indicated that ADSCs may relieve IPF and provide a significant contribution to lung repair when administered at an early stage.
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October-2015
Volume 12 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Jiang H, Zhang J, Zhang Z, Ren S and Zhang C: Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Mol Med Rep 12: 5933-5938, 2015
APA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., & Zhang, C. (2015). Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis. Molecular Medicine Reports, 12, 5933-5938. https://doi.org/10.3892/mmr.2015.4178
MLA
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12.4 (2015): 5933-5938.
Chicago
Jiang, H., Zhang, J., Zhang, Z., Ren, S., Zhang, C."Effect of transplanted adipose‑derived stem cells in mice exhibiting idiopathic pulmonary fibrosis". Molecular Medicine Reports 12, no. 4 (2015): 5933-5938. https://doi.org/10.3892/mmr.2015.4178