Cyclic RNA hsa‑circ‑000595 regulates apoptosis of aortic smooth muscle cells

Zheng,Chengfei; Niu,Hui; Li,Ming; Zhang,Hongkun; Yang,Zhenggang; Tian,Lu; Wu,Ziheng; Li,Donglin; Chen,Xudong

doi:10.3892/mmr.2015.4264

Cyclic RNA hsa‑circ‑000595 regulates apoptosis of aortic smooth muscle cells

Authors:
- Chengfei Zheng
- Hui Niu
- Ming Li
- Hongkun Zhang
- Zhenggang Yang
- Lu Tian
- Ziheng Wu
- Donglin Li
- Xudong Chen
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Affiliations: Department of Cardiac Surgery, Zhejiang First Hospital, Hangzhou, Zhejiang 310009, P.R. China, Academy of Military Medical Sciences, Beijing 100850, P.R. China
Published online on: August 28, 2015 https://doi.org/10.3892/mmr.2015.4264
Pages: 6656-6662
Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Aortic aneurysm is a cardiovascular condition with a serious risk of mortality and the dismal prognosis of any type of major cardiovascular disease. The present study found that tissues from aortic aneurysm patients and hypoxic aortic smooth muscle cells showed aberrant high expression of the cyclic RNA hsa‑circ‑000595, as demonstrated by polymerase chain reaction array screening. Knockdown of hsa‑circ‑000595 resulted in a decreased apoptotic rate of human aortic smooth muscle cells. Furthermore, it was determined that miR‑19a is a target of hsa‑circ‑000595. The results of the present study laid an epigenetic foundation for exploring the underlying mechanisms of the development of aortic aneurysm.

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