Open Access

Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose

  • Authors:
    • Maria Jose Dubon
    • Yeji Byeon
    • Ki‑Sook Park
  • View Affiliations

  • Published online on: October 16, 2015     https://doi.org/10.3892/mmr.2015.4453
  • Pages: 8048-8054
  • Copyright: © Dubon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The rescue of glucose tolerance and insulin‑sensitivity in peripheral tissues, including adipose tissue, is essential in therapeutic strategies for diabetes. The present study demonstrated that substance P (SP) increases the accumulation of lipids in 3T3‑L1 cells during their differentiation into adipocytes in response to a high concentration of glucose. SP reciprocally regulated the activities of AMP‑activated protein kinase (AMPK) and Akt: SP enhanced the activation of AMPK, although the activity of Akt was downregulated. Notably, SP induced an increase in the expression level of glucose transporter 4 in the 3T3‑L1 adipocytes. Therefore, it is possible that SP leads to an increase in glucose uptake and the accumulation of lipids in adipocytes, and may contribute towards the rescue of insulin‑sensitivity in diabetes.
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December-2015
Volume 12 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Dubon MJ, Byeon Y and Park KS: Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose. Mol Med Rep 12: 8048-8054, 2015.
APA
Dubon, M.J., Byeon, Y., & Park, K. (2015). Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose. Molecular Medicine Reports, 12, 8048-8054. https://doi.org/10.3892/mmr.2015.4453
MLA
Dubon, M. J., Byeon, Y., Park, K."Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose". Molecular Medicine Reports 12.6 (2015): 8048-8054.
Chicago
Dubon, M. J., Byeon, Y., Park, K."Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3‑L1 cells in response to high levels of glucose". Molecular Medicine Reports 12, no. 6 (2015): 8048-8054. https://doi.org/10.3892/mmr.2015.4453