Role of long noncoding RNAs in malignant disease (Review)

  • Authors:
    • Ying Li
    • Xin Wang
  • View Affiliations

  • Published online on: December 23, 2015     https://doi.org/10.3892/mmr.2015.4711
  • Pages: 1463-1469
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Abstract

Long noncoding RNAs (lncRNAs) are endogenous transcribed RNA molecules without protein-coding potential, ranging between 200 and 100,000 nt in length. LncRNAs regulate the expression of specific genes in several ways, including guiding chromatin‑remodeling, and affecting splicing, transcription or translation. The mutations and dysregulation of lncRNAs have been found to be important in various human diseases, but particularly in human cancer. Previous studies have demonstrated that changes to lncRNAs are closely associated with tumorigenesis, metastasis, prognosis and diagnosis. The current review aims to present a brief overview of the associated reports of lncRNAs in malignant neoplasms, including breast cancer, prostate cancer and hematological malignancies. LncRNAs may be evaluated as novel markers in disease diagnosis, and as prospective therapeutic targets for the prevention and treatment of human diseases.
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February-2016
Volume 13 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li Y and Li Y: Role of long noncoding RNAs in malignant disease (Review). Mol Med Rep 13: 1463-1469, 2016
APA
Li, Y., & Li, Y. (2016). Role of long noncoding RNAs in malignant disease (Review). Molecular Medicine Reports, 13, 1463-1469. https://doi.org/10.3892/mmr.2015.4711
MLA
Li, Y., Wang, X."Role of long noncoding RNAs in malignant disease (Review)". Molecular Medicine Reports 13.2 (2016): 1463-1469.
Chicago
Li, Y., Wang, X."Role of long noncoding RNAs in malignant disease (Review)". Molecular Medicine Reports 13, no. 2 (2016): 1463-1469. https://doi.org/10.3892/mmr.2015.4711