Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma

  • Authors: Su Youn Yim, You Jin Lee, Yoen Kyung Lee, Seung Eun Jung, Ji Ha Kim, Hak Jin Kim, Beung Gu Son, Young Hoon Park, Young Guen Lee, Young Whan Choi, Dae Youn Hwang
  • View Affiliations

  • Published online on: Tuesday, September 1, 2009
  • Pages: 725-732
  • DOI: 10.3892/mmr_00000163

Abstract

Lignans isolated from Schisandria chinensis have been prescribed as anti-cancer and anti-hepatitis treatments in Chinese medicine. To investigate the applications of lignans isolated from Schisandria chinensis in hepatic carcinoma therapy, their apoptotic ability was screened using a cell proliferation assay. Compared to the other lignans, gomisin N induced high apoptotic levels in hepatic carcinoma. Cell morphology and flow cytometric analysis demonstrated that this lignan induced cell death at high concentrations, but did not induce any changes at low concentrations. In addition, the expression levels of Bcl-2 and Bax proteins, which are involved in the apoptotic pathway, were markedly increased in only the 320 ┬ÁM-treated group compared to the vehicle and other concentration groups, while the expression level of p53 protein remained unchanged in this group. These results suggest that gomisin N is an anti-cancer drug candidate capable of inhibiting the proliferation and inducing the apoptosis of human hepatic carcinomas.
Journal Cover

September 2009
Volume 2 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

2013 Impact Factor: 1.484
Ranked #59/122 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Yim, S., Lee, Y., Lee, Y., Jung, S., Kim, J., Kim, H., Son, B., Park, Y., Lee, Y., Choi, Y., & Hwang, D. (2009). Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma. Molecular Medicine Reports, 2(5), 725-732.
MLA
Yim, Lee, Lee, Jung, Kim, Kim, Son, Park, Lee, Choi, and Dae Hwang. "Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma." Molecular Medicine Reports Molecular Medicine Reports 2.5 (2009): 725-732.
Chicago
Yim, Lee, Lee, Jung, Kim, Kim, Son, Park, Lee, Choi, and Dae Hwang. "Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma." Molecular Medicine Reports Molecular Medicine Reports 2 no. 5 (2009): 725-732.