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Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro

  • Authors:
    • Min Pang
    • Chun-Lei Gao
    • Zhen-Xing Wu
    • Ning Lv
    • Zong-Ling Wang
    • Xue-Xi Tang
    • Pei Qu

  • View Affiliations

  • Published online on: July 1, 2010     https://doi.org/10.3892/mmr_00000307
  • Pages: 629-634
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

To investigate the apoptotic effects of an extract of red-tide algae, Protoceratium reticulatum, on HeLa cells, we used liquid chromatography-tandem mass spectrometry, optical microscopy, Hoechst 33342/propidine iodide staining, and DNA gel electrophoresis to analyze its constituents and toxicity, as well as rhodamine 123 staining to investigate changes in mitochondrial membrane potential. Analysis showed that the P. reticulatum extract contained the yessotoxins (YTXs) homo-YTX, 45-OH-YTX and 45-OH-homo-YTX. The results indicated that P. reticulatum extract negatively influences HeLa cells and induces their apoptosis.

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July-August 2010
Volume 3 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Journal Metrics
  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 6.9
  • CiteScore Rank: Q2: #98/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.721
  • SCImago Journal Rank (SJR): 0.65
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Spandidos Publications style
Pang M, Gao C, Wu Z, Lv N, Wang Z, Tang X and Qu P: Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro . Mol Med Rep 3: 629-634, 2010
APA
Pang, M., Gao, C., Wu, Z., Lv, N., Wang, Z., Tang, X., & Qu, P. (2010). Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro . Molecular Medicine Reports, 3, 629-634. https://doi.org/10.3892/mmr_00000307
MLA
Pang, M., Gao, C., Wu, Z., Lv, N., Wang, Z., Tang, X., Qu, P."Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro ". Molecular Medicine Reports 3.4 (2010): 629-634.
Chicago
Pang, M., Gao, C., Wu, Z., Lv, N., Wang, Z., Tang, X., Qu, P."Apoptosis induced by yessotoxins in Hela human cervical cancer cells in vitro ". Molecular Medicine Reports 3, no. 4 (2010): 629-634. https://doi.org/10.3892/mmr_00000307