Excess of activating killer cell immunoglobulin‑like receptors and lack of HLA-Bw4 ligands: A two‑edged weapon in chronic fatigue syndrome

  • Authors: Annamaria Pasi, Sara Bozzini, Nicoletta Carlo-Stella, Miryam Martinetti, Stefano Bombardieri, Annalisa De Silvestri, Laura Salvaneschi, Mariaclara Cuccia
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  • Published online on: Friday, March 4, 2011
  • Pages: 535-540
  • DOI: 10.3892/mmr.2011.447

Abstract

Chronic fatigue syndrome (CFS) is an inflammatory disease of unknown aetiology. Researchers have proposed infectious, neurological and immunological causes of this syndrome. Recently, the xenotropic murine leukemia virus-related virus was detected in 67% of patients with CFS in a US study. This observation is in agreement with one ascertained aspect of the disease: a decreased efficiency in NK cell lytic activity in CFS patients. Here, we analyzed the genomic polymorphism of killer cell immunoglobulin-like receptors (KIRs) and their HLA class I cognate ligands in patients with certified CFS. An excess of KIR3DS1 was found in CFS patients with respect to controls, as well as an increased frequency of the genotype missing KIR2DS5. Forty-four CFS patients and 50 controls also underwent genomic typing for the HLA-ligands. In the patients, a great proportion of KIR3DL1 and KIR3DS1 receptors were found to be missing their HLA-Bw4Ile80 binding motif. We hypothesize that an excess of KIR3DS1, combined with an excess of ligand-free KIR3DL1 and KIR3DS1 receptors, may hamper the clearance of a pathogen via NK cells, thus favouring the chronicity of the infection.
Journal Cover

May 2011
Volume 4 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

2013 Impact Factor: 1.484
Ranked #59/122 Medicine Research and Experimental
(total number of cites)

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APA
Pasi, A., Bozzini, S., Carlo-Stella, N., Martinetti, M., Bombardieri, S., De Silvestri, A., Salvaneschi, L., & Cuccia, M. (2011). Excess of activating killer cell immunoglobulin‑like receptors and lack of HLA-Bw4 ligands: A two‑edged weapon in chronic fatigue syndrome. Molecular Medicine Reports, 4(3), 535-540.
MLA
Pasi, Bozzini, Carlo-Stella, Martinetti, Bombardieri, De Silvestri, Salvaneschi, and Mariaclara Cuccia. "Excess of activating killer cell immunoglobulin‑like receptors and lack of HLA-Bw4 ligands: A two‑edged weapon in chronic fatigue syndrome." Molecular Medicine Reports Molecular Medicine Reports 4.3 (2011): 535-540.
Chicago
Pasi, Bozzini, Carlo-Stella, Martinetti, Bombardieri, De Silvestri, Salvaneschi, and Mariaclara Cuccia. "Excess of activating killer cell immunoglobulin‑like receptors and lack of HLA-Bw4 ligands: A two‑edged weapon in chronic fatigue syndrome." Molecular Medicine Reports Molecular Medicine Reports 4 no. 3 (2011): 535-540.