Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas

Kondratov,A. G.; Stoliar,L. A.; Kvasha,S. M.; Gordiyuk,V. V.; Zgonnyk,Y. M.; Gerashchenko,A. V.; Vozianov,A. F.; Rynditch,A. V.; Zabarovsky,E. R.; Kashuba,V. I.

doi:10.3892/mmr.2011.681

Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas

Authors:
- A. G. Kondratov
- L. A. Stoliar
- S. M. Kvasha
- V. V. Gordiyuk
- Y. M. Zgonnyk
- A. V. Gerashchenko
- A. F. Vozianov
- A. V. Rynditch
- E. R. Zabarovsky
- V. I. Kashuba
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Affiliations: Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine, Institute of Urology, Academy of Medical Sciences, 04053 Kiev, Ukraine, Department of Functional Genomics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine, MTC, Karolinska Institute, Stockholm 17177, Sweden
Published online on: November 16, 2011 https://doi.org/10.3892/mmr.2011.681
Pages: 509-512

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Abstract

The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found.