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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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February 2012 Volume 5 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention

  • Authors:
    • Enzo Berardesca
    • Marco Bertona
    • Karmela Altabas
    • Velimir Altabas
    • Enzo Emanuele

  • View Affiliations / Copyright

    Affiliations: San Gallicano Dermatological Institute, IRCCS, Rome, Italy, Department of Health Sciences, University of Pavia, I-27100 Pavia, Italy, Department of Internal Medicine, Clinical Hospital ‘Sestre Milosrdnice’, Zagreb, Croatia
  • Pages: 570-574
    |
    Published online on: November 11, 2011
       https://doi.org/10.3892/mmr.2011.673
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Abstract

The exposure of human skin to ultraviolet radiation (UVR) results in the formation of DNA photolesions that give rise to photoaging, mutations, cell death and the onset of carcinogenic events. Photolyase (EC 4.1.99.3) is a DNA repair enzyme that reverses damage caused by exposure to UVR. We sought to investigate whether addition of photolyase enhances the protection provided by a traditional sunscreen (SS), by reducing the in vivo formation of cyclobutane-type pyrimidine dimers (CPDs) and UVR-induced apoptosis in human skin. Ten volunteers (Fitzpatrick skin type II) were exposed to solar-simulated (ss) UVR at a three times minimal erythema dose for 4 consecutive days. Thirty minutes prior to each exposure, the test materials [vehicle, SS (sun protection factor 50) alone, and SS plus photolyase from Anacystis nidulans] were applied topically to three different sites. One additional site was left untreated and one received ssUVR only. Biopsy specimens were taken 72 h after the last irradiation. The amount of CPDs and the extent of apoptosis were measured by ELISA. Photolyase plus SS was superior to SS alone in reducing both the formation of CPDs and apoptotic cell death (both P<0.001). In conclusion, the addition of photolyase to a traditional SS contributes significantly to the prevention of UVR-induced DNA damage and apoptosis when applied topically to human skin.

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Copy and paste a formatted citation
Spandidos Publications style
Berardesca E, Bertona M, Altabas K, Altabas V and Emanuele E: Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention. Mol Med Rep 5: 570-574, 2012.
APA
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., & Emanuele, E. (2012). Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention. Molecular Medicine Reports, 5, 570-574. https://doi.org/10.3892/mmr.2011.673
MLA
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., Emanuele, E."Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention". Molecular Medicine Reports 5.2 (2012): 570-574.
Chicago
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., Emanuele, E."Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention". Molecular Medicine Reports 5, no. 2 (2012): 570-574. https://doi.org/10.3892/mmr.2011.673
Copy and paste a formatted citation
x
Spandidos Publications style
Berardesca E, Bertona M, Altabas K, Altabas V and Emanuele E: Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention. Mol Med Rep 5: 570-574, 2012.
APA
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., & Emanuele, E. (2012). Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention. Molecular Medicine Reports, 5, 570-574. https://doi.org/10.3892/mmr.2011.673
MLA
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., Emanuele, E."Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention". Molecular Medicine Reports 5.2 (2012): 570-574.
Chicago
Berardesca, E., Bertona, M., Altabas, K., Altabas, V., Emanuele, E."Reduced ultraviolet-induced DNA damage and apoptosis in human skin with topical application of a photolyase-containing DNA repair enzyme cream: Clues to skin cancer prevention". Molecular Medicine Reports 5, no. 2 (2012): 570-574. https://doi.org/10.3892/mmr.2011.673
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