Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia

Li,Wei‑Zu; Wu,Wang‑Yang; Huang,Huan; Wu,Yang‑Yang; Yin,Yan‑Yan

doi:10.3892/mmr.2013.1573

Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia

Authors:
- Wei‑Zu Li
- Wang‑Yang Wu
- Huan Huang
- Yang‑Yang Wu
- Yan‑Yan Yin
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Affiliations: Department of Pharmacology, Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, P.R. China
Published online on: July 8, 2013 https://doi.org/10.3892/mmr.2013.1573
Pages: 935-941

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Abstract

Vascular dementia (VD) is the second most common type of dementia in the elderly. Currently, there are no effective drugs for preventing or decreasing the progression of dementia. Bilobalide (BB) is a monomer extracted from Ginkgo biloba leaves. The present study investigated the neuroprotective effects of BB in a two‑vessel occlusion (2‑VO)‑induced VD rat model. The results showed that BB (4 and 8 mg/kg) significantly protected VD rats against cognitive deficits in the Morris water maze. Biochemical assessment showed that BB (4 and 8 mg/kg) increased superoxide dismutase (SOD) activity and glutathione (GSH) content, and decreased nitric oxide synthase (NOS) activity and malondialdehyde (MDA) content. Additionally, BB (4 and 8 mg/kg) was found to alleviate neuronal apoptosis and to reduce the expression of tumor necrosis factor‑α (TNF‑α) in the brain cortex and the hippocampal CA1 region in VD rats. These results suggest that BB provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal CA1 region in VD rats.

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