The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis

  • Authors:
    • Kazuhiro Matsunaga
    • Tomomitsu Tahara
    • Hisakazu  Shiroeda
    • Toshimi  Otsuka
    • Masakatsu Nakamura
    • Takeo Shimasaki
    • Nobuyuki  Toshikuni
    • Natsuko  Kawada
    • Tomoyuki Shibata
    • Tomiyasu Arisawa
  • View Affiliations

  • Published online on: Friday, November 1, 2013
  • Pages: 28-32
  • DOI: 10.3892/mmr.2013.1769

Abstract

Toll‑like receptor activation intitially recruits the myeloid differentiation primary response gene (88) (MyD88) protein. A polymorphism *1244 A>G (rs7744) in the 3'‑untranslated region of MyD88 has been identified. In the present study, the association of this polymorphism with ulcerative colitis (UC) was investigated. The population studied comprised 922 individuals, including patients with UC (UC cases) and without (controls). Genotyping of rs7744 was performed by PCR single-strand conformation polymorphism and the rs7744 G allele frequencies in the controls and UC cases were 32.8 and 43.5%, respectively (P<0.0001). The results showed that the genotype frequency of the AA homozygote was significantly lower and that of the GG homozygote was significantly higher in the UC cases compared with those in the controls (P=0.0012 for both groups). The rs7744 minor allele variants were significantly associated with susceptibility to UC as indicated by dominant and recessive genetic models. The minor allele variants were associated with an increased risk for UC in the male individuals but not the female individuals. The rs7744 was also associated with a non‑continuous phenotype of UC and steroid unused/independent UC. This minor allele homozygote was associated with the disease severity of UC, hospitalization and response to steroid treatment. The results of the present study provided evidence that MyD88 polymorphism rs7744 was significantly associated with the development of UC and that this polymorphism may be associated with the response to treatment therapies for UC.
Journal Cover

January 2014
Volume 9 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

2013 Impact Factor: 1.484
Ranked #59/122 Medicine Research and Experimental
(total number of cites)

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APA
Matsunaga, K., Tahara, T., Shiroeda, H., Otsuka, T., Nakamura, M., Shimasaki, T., Toshikuni, N., Kawada, N., Shibata, T., & Arisawa, T. (2014). The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis. Molecular Medicine Reports, 9(1), 28-32.
MLA
Matsunaga, Tahara, Shiroeda, Otsuka, Nakamura, Shimasaki, Toshikuni, Kawada, Shibata, and Tomiyasu Arisawa. "The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis." Molecular Medicine Reports Molecular Medicine Reports 9.1 (2014): 28-32.
Chicago
Matsunaga, Tahara, Shiroeda, Otsuka, Nakamura, Shimasaki, Toshikuni, Kawada, Shibata, and Tomiyasu Arisawa. "The *1244 A>G polymorphism of MyD88 (rs7744) is closely associated with susceptibility to ulcerative colitis." Molecular Medicine Reports Molecular Medicine Reports 9 no. 1 (2014): 28-32.