β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats

  • Authors:
    • Heeok Hong
    • Chang‑Ju Kim
    • Jae‑Deung Kim
    • Jin‑Hee Seo
  • Corresponding author:
  • View Affiliations

  • Published online on: Tuesday, March 4, 2014
  • Pages: 1660-1666 DOI: 10.3892/mmr.2014.2005

Abstract

Immediate‑early genes are involved in acute stress responses in the central nervous system. β‑glucan stimulates innate immune defenses, exerts an anti‑tumor response and increases resistance to a wide variety of types of infection. To date, the effect of β‑glucan on the expression of immediate‑early genes under stressful conditions has not been elucidated. In the present study, the effects of β‑glucan on the expression of the oncogenes c‑Fos and c‑Jun in the hypothalamus, dentate gyrus and dorsal raphe in rats following exhaustive treadmill running were investigated. Male Sprague Dawley rats were randomly divided into five groups (n=10 in each group) as follows: Control, exercise, exercise and 50 mg/kg β‑glucan treatment, exercise and 100 mg/kg β‑glucan treatment, and exercise and 200 mg/kg β‑glucan treatment. Rats in the β‑glucan‑treated groups were administered β‑glucan at the respective dose once per day for seven days. Rats in the exercise groups performed treadmill running once per day for six days. On the seventh day of the experiment, the time to exhaustion in response to treadmill running was determined for the exercise groups. The expression of c‑Fos and c‑Jun in the hypothalamus, dorsal raphe and hippocampus was enhanced by exhaustive treadmill running. Administration of β‑glucan resulted in an increase in the time to exhaustion and the suppression of the exercise‑induced increment in c‑Fos and c‑Jun expression. In conclusion, β‑glucan may exert an alleviating effect on exercise‑induced stress through the suppression of c‑Fos and c‑Jun expression in the brains of exhausted rats.
Journal Cover

May 2014
Volume 9 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

2013 Impact Factor: 1.484
2014 I.F. (Expected) ≥ 1.757 Ranked #59/122 Medicine Research and Experimental
(total number of cites)

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APA
Hong, H., Kim, C., Kim, J., & Seo, J. (2014). β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats. Molecular Medicine Reports, 9, 1660-1666. http://dx.doi.org/10.3892/mmr.2014.2005
MLA
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9.5 (2014): 1660-1666.
Chicago
Hong, H., Kim, C., Kim, J., Seo, J."β‑glucan reduces exercise‑induced stress through downregulation of c‑Fos and c‑Jun expression in the brains of exhausted rats". Molecular Medicine Reports 9, no. 5 (2014): 1660-1666. http://dx.doi.org/10.3892/mmr.2014.2005