Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Kobatake,Kohei; Mita,Koji; Ohara,Shinya; Kato,Masao

doi:10.3892/ol.2015.3280

Advantage of transurethral resection with narrow band imaging for non-muscle invasive bladder cancer

Authors:
- Kohei Kobatake
- Koji Mita
- Shinya Ohara
- Masao Kato
View Affiliations

Affiliations: Department of Urology, Hiroshima City Asa Hospital, Hiroshima 731‑0293, Japan
Published online on: May 27, 2015 https://doi.org/10.3892/ol.2015.3280
Pages: 1097-1102

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The aim of the present study was to compare the benefits of transurethral resection (TUR) under narrow band imaging (NBI-TUR) and TUR under conventional white light imaging (WLI-TUR) for non‑muscle invasive bladder cancer (NMIBC). The study cohort consisted of 135 patients with NMIBC who were followed up for ≥1 year after TUR and who received no additional post‑operative treatment. In the WLI‑TUR group (n=78), systematic intravesical observation under WLI was followed by a multiple site biopsy (MSB), after which lesions detected as positive findings were resected completely under WLI. In the NBI‑TUR group (n=57), similar observation under WLI was followed by systematic intravesical observation under NBI. Following MSB under NBI, TUR was performed for all lesions detected as positive findings under NBI. The sensitivity, specificity, positive‑predictive value, negative‑predictive value (NPV) and accuracy in the NBI‑TUR group were calculated using results from the cystoscopical and pathological examinations of MSB samples under WLI and NBI. The tumor recurrence rate was analyzed in the two groups. Background factors did not differ significantly between the two groups, with the exception of the observation period (31.0 vs. 15.0 months; P<0.01). The procedure under NBI exhibited significantly higher sensitivity (95.0 vs. 70.0%; P<0.01) and NPV (97.1 vs. 86.8%; P<0.01) compared with the procedure under WLI. The 1‑year recurrence rate in the NBI‑TUR group was significantly lower than that in the WLI‑TUR group (21.1 vs. 39.7%; P=0.016). In conclusion, the present study indicated that NBI‑TUR is more advantageous than conventional WLI-TUR for patients with NMIBC.

View Figures

View References

1	Olympus, . News release. December 26–2006 Endoscopic videoscope system. http://www.olympus-europa.com/medical/en/medical_systems/applications/urology/bladder/narrow_band_imaging__nbi_/narrow_band_imaging__nbi_.htmlAccessed. April 22–2015
2	Hirata I, Nakagawa Y, Ohkubo M, Yahagi N and Yao K: Usefulness of magnifying narrow-band imaging endoscopy for the diagnosis of gastric and colorectal lesions. Digestion. 85:74–79. 2012. View Article : Google Scholar : PubMed/NCBI
3	Bryan RT, Billingham LJ and Wallace DM: Narrow-band imaging flexible cystoscopy in the detection of recurrent urothelial cancer of the bladder. BJU Int. 101:702–706. 2008. View Article : Google Scholar : PubMed/NCBI
4	Naselli A, Introini C, Timossi L, et al: A randomized prospective trial to assess the impact of transurethral resection in narrow band imaging modality on non-muscle-invasive bladder cancer recurrence. Eur Urol. 61:908–913. 2012. View Article : Google Scholar : PubMed/NCBI
5	Cauberg EC, Mamoulakis C, de la Rosette JJ and de Reijke TM: Narrow band imaging-assisted transurethral resection for non-muscle invasive bladder cancer significantly reduces residual tumor rate. World J Urol. 29:503–509. 2011. View Article : Google Scholar : PubMed/NCBI
6	Naselli A, Introini C, Bertolotto F, Spina B and Puppo P: Narrow band imaging for detecting residual/recurrent cancerous tissue during second transurethral resection of newly diagnosed non-muscle-invasive high-grade bladder cancer. BJU Int. 105:208–211. 2010. View Article : Google Scholar : PubMed/NCBI
7	Tatsugami K, Kuroiwa K, Kamoto T, et al: Evaluation of narrow-band imaging as a complementary method for the detection of bladder cancer. J Endourol. 24:1807–1811. 2010. View Article : Google Scholar : PubMed/NCBI
8	Cauberg EC, Kloen S, Visser M, et al: Narrow band imaging cystoscopy improves the detection of non-muscle-invasive bladder cancer. Urology. 76:658–663. 2010. View Article : Google Scholar : PubMed/NCBI
9	Herr HW and Donat SM: A comparison of white-light cystoscopy and narrow-band imaging cystoscopy to detect bladder tumour recurrences. BJU Int. 102:1111–1114. 2008. View Article : Google Scholar : PubMed/NCBI
10	Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Böhle A and Palou-Redorta JEuropean Association of Urology (EAU): EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol. 54:303–314. 2008.
11	Brausi M, Collette L, Kurth K, van der Meijden AP, et al EORTC Genito-Urinary Tract Cancer Collaborative Group: Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: A combined analysis of seven EORTC studies. Eur Urol. 41:523–531. 2002. View Article : Google Scholar : PubMed/NCBI
12	Brausi M: Are new technologies for detection and treatment of non-muscle-invasive bladder cancer (NMIBC) so important? A plea for adoption by teaching programs to improve results after standard white light transurethral resection of NMIBC. Eur Urol. 61:914–916. 2012. View Article : Google Scholar : PubMed/NCBI
13	Sylvester RJ, van der Meijden AP, Oosterlinck W, et al: Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol. 49:466–477. 2006. View Article : Google Scholar : PubMed/NCBI
14	Daniltchenko DI, Riedl CR, Sachs MD, et al: Long-term benefit of 5-aminolevulinic acid fluorescence assisted transurethral resection of superficial bladder cancer: 5-year results of a prospective randomized study. J Urol. 174:2129–2133. 2005. View Article : Google Scholar : PubMed/NCBI
15	Schumacher MC, Holmäng S, Davidsson T, Friedrich B, Pedersen J and Wiklund NP: Transurethral resection of non-muscle-invasive bladder transitional cell cancers with or without 5-aminolevulinic acid under visible and fluorescent light: results of a prospective, randomised, multicentre study. Eur Urol. 57:293–299. 2010. View Article : Google Scholar : PubMed/NCBI
16	Clinical Research Office of the Endourological society, . The Global Randomized NBI Bladder Cancer study. http://www.croesoffice.org/OngoingProjects/NBIStudy.aspx
17	Botteman MF, Pashos CL, Radaelli A, Laskin B and Hauser R: The health economics of bladder cancer: A comprehensive review of the published literature. Pharmacoeconomics. 21:1315–1330. 2003. View Article : Google Scholar : PubMed/NCBI