Impaired glucose metabolism treatment and carcinogenesis (Review)

  • Authors:
    • Artur Matyszewski
    • Anna Czarnecka
    • Maciej Kawecki
    • Piotr Korzeń
    • Ilan J. Safir
    • Wojciech Kukwa
    • Cezary Szczylik
  • View Affiliations

  • Published online on: June 4, 2015     https://doi.org/10.3892/ol.2015.3324
  • Pages: 589-594
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Abstract

Carbohydrate metabolism disorders increase the risk of carcinogenesis. Diabetes mellitus alters numerous physiological processes that may encourage cancer growth. However, treating impaired glucose homeostasis may actually promote neoplasia; maintaining proper glucose plasma concentrations reduces metabolic stresses, however, certain medications may themselves result in oncogenic effects. A number of previous studies have demonstrated that metformin reduces the cancer risk. However, the use of sulfonylurea derivatives correlates with an increased risk of developing a malignancy. Another form of treatment, insulin therapy, involves using various forms of insulin that differ in pharmacodynamics, pharmacokinetics and efficacy. Previous studies have indicated that certain insulin variants also affect the cancer risk. The results from analyses that address the safety of long‑lasting insulin types raise the most concern regarding the increased risk of malignancy. Rapid development of novel diabetic medications and their widespread use carries the risk of potentially increased rates of cancer, unnoticeable in limited, randomized, controlled trials. In the present review, the results of clinical and epidemiological studies are evaluated to assess the safety of anti‑hyperglycemic medications and their effect on cancer risk and outcomes.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Matyszewski A, Czarnecka A, Kawecki M, Korzeń P, Safir IJ, Kukwa W and Szczylik C: Impaired glucose metabolism treatment and carcinogenesis (Review). Oncol Lett 10: 589-594, 2015
APA
Matyszewski, A., Czarnecka, A., Kawecki, M., Korzeń, P., Safir, I.J., Kukwa, W., & Szczylik, C. (2015). Impaired glucose metabolism treatment and carcinogenesis (Review). Oncology Letters, 10, 589-594. https://doi.org/10.3892/ol.2015.3324
MLA
Matyszewski, A., Czarnecka, A., Kawecki, M., Korzeń, P., Safir, I. J., Kukwa, W., Szczylik, C."Impaired glucose metabolism treatment and carcinogenesis (Review)". Oncology Letters 10.2 (2015): 589-594.
Chicago
Matyszewski, A., Czarnecka, A., Kawecki, M., Korzeń, P., Safir, I. J., Kukwa, W., Szczylik, C."Impaired glucose metabolism treatment and carcinogenesis (Review)". Oncology Letters 10, no. 2 (2015): 589-594. https://doi.org/10.3892/ol.2015.3324