search button

A 10‑gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma

  • Authors:
    • Fang Chen
    • Naifu Liu

  • View Affiliations

  • Published online on: June 16, 2015     https://doi.org/10.3892/ol.2015.3382
  • Pages: 1704-1708
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Patients with ovarian carcinoma are at high risk of tumor recurrence. In the present study, 81 Notch pathway genes were selected to find recurrence‑related genes in The Cancer Genome Atlas dataset. A 10‑gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified and validated that is associated with recurrence‑free survival time, but not with overall survival time, in the TCGA dataset and in other two independent datasets, GSE9891 and GSE30161. This gene signature gave a significant performance in discriminating patients at high risk of recurrence from those at low risk, as measured by the area under the receiver operating characteristic curve. Cox proportional hazards regression analyses demonstrated that the prognostic value of this 10‑gene set is independent of other clinical variables in all three datasets. The potential as a biomarker for predicting high‑ and low‑risk subgroups for recurrence in ovarian cancer patients deserves further investigation in prospective patient cohorts in the future.
View Figures
View References

Related Articles

Journal Cover

September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Chen F and Chen F: A 10‑gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma. Oncol Lett 10: 1704-1708, 2015
APA
Chen, F., & Chen, F. (2015). A 10‑gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma. Oncology Letters, 10, 1704-1708. https://doi.org/10.3892/ol.2015.3382
MLA
Chen, F., Liu, N."A 10‑gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma". Oncology Letters 10.3 (2015): 1704-1708.
Chicago
Chen, F., Liu, N."A 10‑gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma". Oncology Letters 10, no. 3 (2015): 1704-1708. https://doi.org/10.3892/ol.2015.3382