Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells

Obayashi,Tomohiko; Funasaka,Kohei; Ohno,Eizaburo; Miyahara,Ryoji; Hirooka,Yoshiki; Hamaguchi,Michinari; Goto,Hidemi; Senga,Takeshi

doi:10.3892/ol.2015.3399

Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells

Authors:
- Tomohiko Obayashi
- Kohei Funasaka
- Eizaburo Ohno
- Ryoji Miyahara
- Yoshiki Hirooka
- Michinari Hamaguchi
- Hidemi Goto
- Takeshi Senga
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Affiliations: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
Published online on: June 19, 2015 https://doi.org/10.3892/ol.2015.3399
Pages: 1836-1840

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Abstract

Cancer remains one of the leading causes of human mortality worldwide. Radiation and chemotherapy are commonly used for cancer treatment; however, the combination of these therapies and surgery do not completely eradicate cancer cells. Near‑infrared radiation (NIR) is a low‑energy form of radiation that exerts multiple effects on mammalian cells. Previous studies have reported that NIR induces DNA double‑strand breaks and apoptosis of cancer cells. In the present study, a 915‑nm laser was used to examine the effects of NIR on pancreatic cancer cells. Irradiation of pancreatic cancer cells using a 915‑nm laser significantly induced caspase‑3 activation and apoptosis. In addition, the combination of gemcitabine treatment and a 915‑nm laser synergistically increased the number of apoptotic cells. The results of the present study indicate the use of infrared irradiation and chemotherapy may be a possible therapy for the treatment of cancer.

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