Optimal treatment for primary benign intratracheal schwannoma: A case report and review of the literature

Ge,Xiahui; Han,Fengfeng; Guan,Wenbin; Sun,Jinyuan; Guo,Xuejun

doi:10.3892/ol.2015.3521

Optimal treatment for primary benign intratracheal schwannoma: A case report and review of the literature

Authors:
- Xiahui Ge
- Fengfeng Han
- Wenbin Guan
- Jinyuan Sun
- Xuejun Guo
View Affiliations

Affiliations: Department of Respiratory Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China, Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China
Published online on: July 21, 2015 https://doi.org/10.3892/ol.2015.3521
Pages: 2273-2276

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

A 53-year-old male was admitted to Xinhua Hospital (Shanghai, China) due to coughing and dyspnea that had persisted for half a year, with aggravation of chest tightness and dyspnea for 1 week. Chest computed tomography (CT) revealed a mass within the distal third of the trachea. Flexible bronchoscopy confirmed an ~2.0 cm, smooth, tan‑colored mass in the trachea, 2 cm above the carina. Endoscopic resection by argon plasma coagulation combined with electronic snaring was applied, however, recurrence was found 2 weeks later. Finally, the tumor was completely removed by surgery and the post‑operative course was uneventful. Since schwannoma is rare in the intrapulmonary region and extremely rare in the trachea, a review of 51 cases of primary tracheal schwannoma previously reported in the English literature was performed. The majority of cases occurred in adults and were usually located in the distal third of the trachea. The predominant tumor size was 1‑3 cm and airway obstruction symptoms were common. Half of the patients were misdiagnosed with asthma, and CT scan and bronchoscopy were contributory to the correct diagnosis. The treatment of choice depended on the patient's condition, however, surgery should be chosen in the event of local recurrence following endoscopic treatment.

View Figures

View References

1	Davies MJ, Hall DR and Ross BA: Rare tracheal tumours: Two case reports of primary neurogenic tumours occurring in the trachea. Respir Med. 87:145–146. 1993. View Article : Google Scholar : PubMed/NCBI
2	Tang LF, Chen ZM and Zou CC: Primary intratracheal neurilemmoma in children: Case report and literature review. Pediatr Pulmonol. 40:550–553. 2005. View Article : Google Scholar : PubMed/NCBI
3	Righini CA, Lequeux T, Laverierre MH and Reyt E: Primary tracheal schwannoma: One case report and a literature review. Eur Arch Otorhinolaryngol. 262:157–160. 2005. View Article : Google Scholar : PubMed/NCBI
4	Kasahara K, Fukuoka K, Konishi M, Hamada K, Maeda K, Mikasa K and Kimura H: Two cases of endobronchial neurilemmoma and review of the literature in Japan. Intern Med. 42:1215–1218. 2003. View Article : Google Scholar : PubMed/NCBI
5	Takeda S, Miyoshi S, Minami M and Matsuda H: Intrathoracic neurogenic tumors-50 years' experience in a Japanese institution. Eur J Cardiothorac Surg. 26:807–812. 2004. View Article : Google Scholar : PubMed/NCBI
6	DasGupta TK, Brasfield RD, Strong EW and Hajdu SI: Benign solitary Schwannomas (neurilemomas). Cancer. 24:355–366. 1969. View Article : Google Scholar : PubMed/NCBI
7	Dutta R, Kumar A, Kaushal S and Choudhary SK: A case of carinal schwannoma resected under cardiopulmonary bypass. Indian J Cancer. 48:366–368. 2011. View Article : Google Scholar : PubMed/NCBI
8	Melendez J, Cornwell L, Green L and Casal RF: Treatment of large subglottic tracheal schwannoma with microdebrider bronchoscopy. J Thorac Cardiovasc Surg. 144:510–512. 2012. View Article : Google Scholar : PubMed/NCBI
9	Erol MM, Uzun H, Tekinbas C, Gunduz A, Turedi S and Kosucu P: A case of intratracheal schwannoma presenting at the emergency department with a diagnosis of asthmatic attack. J Emerg Med. 39:589–591. 2010. View Article : Google Scholar : PubMed/NCBI
10	Shah SS, Karnak D, Shah SN, Biscotti C, Murthy S and Mehta AC: Clinical-pathologic conference in general thoracic surgery: A malignant peripheral nerve sheath tumor of the trachea. J Thorac Cardiovasc Surg. 132:1455–1459. 2006. View Article : Google Scholar : PubMed/NCBI
11	Pang LC: Primary neurilemoma of the trachea. South Med J. 82:785–787. 1989. View Article : Google Scholar : PubMed/NCBI
12	Nio M, Sano N, Kotera A, Shimanuki Y, Takeyama J and Ohi R: Primary tracheal schwannoma (neurilemoma) in a 9-year-old girl. J Pediatr Surg. 40:E5–E7. 2005. View Article : Google Scholar : PubMed/NCBI
13	Dincer SI, Demir A, Kara HV, Fener N and Altin S: Primary tracheal schwannoma: A case report. Acta Chir Belg. 106:254–256. 2006.PubMed/NCBI
14	Takeda K, Horiuchi M, Nakaya M, Yamaguchi K and Fujikawa A: Schwannoma of the trachea; a new resection technique. Auris Nasus Larynx. 30:425–427. 2003. View Article : Google Scholar : PubMed/NCBI
15	Kitagawa H, Kawase H, Wakisaka M, Satou Y, Satou H, Furuta S and Nakada K: Six cases of children with a benign cervical tumor who required tracheostomy. Pediatr Surg Int. 20:51–54. 2004. View Article : Google Scholar : PubMed/NCBI
16	Murata T, Shino M, Yasuoka Y and Chikamatsu K: Subglottic Schwannoma: A report of a rare case that was treated with medial thyrotomy. Am J Otolaryngol. 34:569–573. 2013. View Article : Google Scholar : PubMed/NCBI
17	Hamdan AL, Moukarbel RV, Tawil A, ElKhatib M and Hadi U: Tracheal schwannoma: A misleading entity. Middle East J Anesthesiol. 20:611–613. 2010.PubMed/NCBI
18	Thomas R, Christopher DJ, Thangakunam B and Samuel R: Tracheal schwannoma as a mimic of bronchial asthma. Singapore Med J. 53:e95–e96. 2012.PubMed/NCBI
19	Rusch VW and Schmidt RA: Tracheal schwannoma: management by endoscopic laser resection. Thorax. 49:85–86. 1994. View Article : Google Scholar : PubMed/NCBI
20	Weiner DJ, Weatherly RA, DiPietro MA and Sanders GM: Tracheal schwannoma presenting as status asthmaticus in a sixteen-year-old boy: Airway considerations and removal with the CO2 laser. Pediatr Pulmonol. 25:393–397. 1998. View Article : Google Scholar : PubMed/NCBI
21	Dorfman J, Jamison BM and Morin JE: Primary tracheal schwannoma. Ann Thorac Surg. 69:280–281. 2000. View Article : Google Scholar : PubMed/NCBI
22	Nass RL and Cohen NL: Neurilemoma of the trachea. Arch Otolaryngol. 105:220–221. 1979. View Article : Google Scholar : PubMed/NCBI
23	Horovitz AG, Khalil KG, Verani RR, Guthrie AM and Cowan DF: Primary intratracheal neurilemoma. J Thorac Cardiovasc Surg. 85:313–317. 1983.PubMed/NCBI
24	Jung YY, Hong ME, Han J, Kim TS, Kim J, Shim YM and Kim H: Bronchial schwannomas: Clinicopathologic analysis of 7 cases. Korean J Pathol. 47:326–331. 2013. View Article : Google Scholar : PubMed/NCBI
25	Stouffer CW, Allan RW, Shillingford MS and Klodell CT: Endobronchial schwannoma presenting with bronchial obstruction. Interact Cardiovasc Thorac Surg. 10:133–134. 2010. View Article : Google Scholar : PubMed/NCBI
26	Lee BR, Choi YD, Kim YI, Lim SC and Kwon YS: Endobronchial schwannoma treated by rigid bronchoscopy with argon plasma coagulation. Tuberc Respir Dis. 73:174–177. 2012. View Article : Google Scholar
27	Feldhaus RJ, Anene C and Bogard P: A rare endobrochial neurilemmoma (Schwannoma). Chest. 95:461–462. 1989. View Article : Google Scholar : PubMed/NCBI