Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer

  • Authors:
    • Xiaoming Song
    • Chunhai Fu
    • Xudong Yang
    • Dongfeng Sun
    • Xianqi Zhang
    • Jiandong Zhang
  • View Affiliations

  • Published online on: August 19, 2015     https://doi.org/10.3892/ol.2015.3623
  • Pages: 2283-2288
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Abstract

Tripartite motif-containing 29 (TRIM29) is a member of the tripartite motif (TRIM) protein family. TRIM29 has been reported to be deregulated in a number of cancer types, suggesting the oncogenic function of TRIM29. However, its clinical significance in non‑small cell lung cancer (NSCLC) has not been fully elucidated. In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin‑embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007. High TRIM29 expression was significantly associated with smoking (P=0.012), T stage (P=0.015) and M stage (P=0.003). Furthermore, elevated TRIM29 expression level was correlated with reduced overall (OS) and disease‑free survival. In addition, high TRIM29 expression was an independent prognostic factor for OS [P=0.003, hazard ratio (HR)=2.102, 95% confidence interval (CI), 1.069‑3.193]. In conclusion, these results suggest that TRIM29 may be a useful prognostic marker in NSCLC patients and a potential molecular target for NSCLC treatment.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Song X, Fu C, Yang X, Sun D, Zhang X and Zhang J: Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer. Oncol Lett 10: 2283-2288, 2015
APA
Song, X., Fu, C., Yang, X., Sun, D., Zhang, X., & Zhang, J. (2015). Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer. Oncology Letters, 10, 2283-2288. https://doi.org/10.3892/ol.2015.3623
MLA
Song, X., Fu, C., Yang, X., Sun, D., Zhang, X., Zhang, J."Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer". Oncology Letters 10.4 (2015): 2283-2288.
Chicago
Song, X., Fu, C., Yang, X., Sun, D., Zhang, X., Zhang, J."Tripartite motif-containing 29 as a novel biomarker in non-small cell lung cancer". Oncology Letters 10, no. 4 (2015): 2283-2288. https://doi.org/10.3892/ol.2015.3623