Sequencing study on familial lung squamous cancer

  • Authors:
    • Shaomin Li
    • Lina Wang
    • Zhenchuan Ma
    • Yuefeng Ma
    • Jiangman Zhao
    • Bo Peng
    • Zhe Qiao
  • View Affiliations

  • Published online on: August 7, 2015     https://doi.org/10.3892/ol.2015.3583
  • Pages: 2634-2638
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Abstract

Lung cancer is the leading cause of cancer‑related mortality worldwide. The majority of lung cancers are sporadic, and familial cases are extremely rare. Previous studies have mainly focused on sporadic lung cancer and identified a large quantity of driver genes. However, familial lung cancers are rarer and studied less. The present study recruited a Chinese family in which multiple members had developed lung squamous carcinoma. To find the causative mutations, whole exome sequencing was conducted using a peripheral blood sample of one lung squamous carcinoma patient, and certain variants were validated in more samples. Whole exome sequencing analysis obtained ~2.0 Gb of data (an average of 60x depth for each targeted base), and further validation experiments identified two functional variants in two cancer‑related genes (c.1218delA:p.E406fs in PDE4DIP and C1342A:p.L448I in CLTCL1). This study therefore provides useful sources for the further study of hereditary lung cancer.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Wang L, Ma Z, Ma Y, Zhao J, Peng B and Qiao Z: Sequencing study on familial lung squamous cancer. Oncol Lett 10: 2634-2638, 2015
APA
Li, S., Wang, L., Ma, Z., Ma, Y., Zhao, J., Peng, B., & Qiao, Z. (2015). Sequencing study on familial lung squamous cancer. Oncology Letters, 10, 2634-2638. https://doi.org/10.3892/ol.2015.3583
MLA
Li, S., Wang, L., Ma, Z., Ma, Y., Zhao, J., Peng, B., Qiao, Z."Sequencing study on familial lung squamous cancer". Oncology Letters 10.4 (2015): 2634-2638.
Chicago
Li, S., Wang, L., Ma, Z., Ma, Y., Zhao, J., Peng, B., Qiao, Z."Sequencing study on familial lung squamous cancer". Oncology Letters 10, no. 4 (2015): 2634-2638. https://doi.org/10.3892/ol.2015.3583