Renal cell carcinoma with metachronous metastasis to the contralateral adrenal gland and urinary bladder: A case report

Wang,Kai; Wang,Junkai; Sun,Ji; Zhong,Dachuan; Tai,Shengcheng; Xu,Danfeng; Fan,Yi

doi:10.3892/ol.2015.3722

Renal cell carcinoma with metachronous metastasis to the contralateral adrenal gland and urinary bladder: A case report

Authors:
- Kai Wang
- Junkai Wang
- Ji Sun
- Dachuan Zhong
- Shengcheng Tai
- Danfeng Xu
- Yi Fan
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Affiliations: Department of Urology, Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang 311202, P.R. China, Department of Urology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
Published online on: September 18, 2015 https://doi.org/10.3892/ol.2015.3722
Pages: 2749-2752
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The adrenal gland and urinary bladder are rare localizations of metastases of renal cell carcinoma (RCC). In the present study, a case of metastasis to the contralateral adrenal gland and urinary bladder of clear cell‑type RCC (ccRCC) in the left kidney is reported in a male who had undergone left radical nephrectomy at 55 years of age. Computed tomography (CT) revealed a mass in the right adrenal gland 5 years following surgery, and type‑B ultrasound demonstrated a 1.0‑cm solid space‑occupying lesion in the right wall of the bladder. Consequently, laparoscopic right adrenalectomy and transurethral resection of the bladder tumor were performed. Furthermore, based on histopathological examination and immunohistochemical staining, the patient was pathologically diagnosed with contralateral adrenal gland and urinary bladder metastasis of ccRCC. CT performed at the 1‑year follow‑up detected multiple solid space‑occupying lesions in the right kidney. Therefore, the patient was treated with sunitinib targeted therapy. To date, the patient is generally in good condition, without evident drug side effects or complaints of discomfort.

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1	Choi JB, Yoon BI, Kim SJ, Cho HJ, Hong SH, Choi YJ, Kim SW, Hwang TK and Lee JY: Changes in clinicopathological characteristics of renal cell carcinoma in the past 25 years: A single-center experience. Korean J Urol. 52:110–114. 2011. View Article : Google Scholar : PubMed/NCBI
2	Siegel R, Naishadham D and Jemal A: Cancer statistics. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI
3	Melegari S, Albo G, Rocco B, Verweij F, Abbinante M and de Cobelli O: Metachronous bladder metastases from renal cell carcinoma: A case report and review of the literature. Ecancermedicalscience. 4:1752010.PubMed/NCBI
4	Chung PH, Srinivasan R, Linehan WM, Pinto PA and Bratslavsky G: Renal cell carcinoma with metastases to the gallbladder: Four cases from the National Cancer Institute (NCI) and review of the literature. Urol Oncol. 30:476–481. 2012. View Article : Google Scholar : PubMed/NCBI
5	Kagota M, Irie K, Hosaka K and Takezaki T: Bladder metastasis of renal cell carcinoma; a case study. Hinyokika Kiyo. 53:571–574. 2007.PubMed/NCBI
6	Lau WK, Zincke H, Lohse CM, Cheville JC, Weaver AL and Blute ML: Contralateral adrenal metastasis of renal cell carcinoma: Treatment, outcome and a review. BJU Int. 91:775–779. 2003. View Article : Google Scholar : PubMed/NCBI
7	Brinkmann OA, Semik M and Gosherger G: The role of residual tumor resection in patients with metastatic renal cell carcinoma and partial remission following immunotherapy. Eur Urol. 6:641–645. 2007. View Article : Google Scholar
8	Alt AL, Bllrjian SA, Lohse CM, Costello BA, Leibovich BC and Blute ML: Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer. 117:2873–2882. 2011. View Article : Google Scholar : PubMed/NCBI
9	Kwak C, Park YH, Jeong CW, Lee SE and Ku JH: Metastasectomy without systemic therapy in metastatic renal cell carcinoma: Comparison with conservative treatment. Urol Int. 79:145–151. 2007. View Article : Google Scholar : PubMed/NCBI
10	Martínez-Salamanca JI, Huang WC, Millán I, Bertini R, Bianco FJ, Carballido JA, Ciancio G, Hernández C, Herranz F, Haferkamp A, et al: International Renal Cell Carcinoma-Venous Thrombus Consortium: Prognostic impact of the 2009 UICC/AJCC TNM staging system for renal cell carcinoma with venous extension. Eur Urol. 59:120–127. 2011. View Article : Google Scholar : PubMed/NCBI
11	Shoji S, Mukai M, Yazawa N, Sekido Y, Nagata Y, Uchida T and Terachi T: Metastasis to gallbladder and adrenal gland of renal cell carcinoma. Oncol Lett. 1:507–509. 2010. View Article : Google Scholar : PubMed/NCBI
12	Moslemi MK, Saghafi H and Firoozabadi MH: Renal cell carcinoma with simultaneous bilateral adrenal metastasis: Ipsilateral radical nephrectomy with contralateral adrenal preservation. Case Rep Oncol. 3:372–379. 2010. View Article : Google Scholar : PubMed/NCBI
13	Saitoh H: Distant metastasis of renal cell adenocarcinoma. Cancer. 48:1487–1491. 1981. View Article : Google Scholar : PubMed/NCBI
14	Shiraishi K, Mohri J, Inoue R and Kamiryo Y: Metastatic renal cell carcinoma to the bladder 12 years after radical nephrectomy. Int J Urol. 10:453–455. 2003. View Article : Google Scholar : PubMed/NCBI
15	Dieckmann KP, Wullbrand A and Krolzig G: Contralateral adrenal metastasis in renal cell cancer. Scand J Urol Nephrol. 30:139–143. 1996. View Article : Google Scholar : PubMed/NCBI
16	Sagalowsky AI, Kadesky KT, Ewalt DM and Kennedy TJ: Factors influencing adrenal metastasis in renal cell carcinoma. J Urol. 151:1181–1184. 1994.PubMed/NCBI
17	Joshi DP, Shah RB, Montie JE and Lee CT: Isolated recurrent renal cell carcinoma metastatic to the bladder. J Natl Med Assoc. 94:912–914. 2002.PubMed/NCBI
18	Utsumi T, Suzuki H, Nakamura K, Kim W, Kamijima S, Awa Y, Araki K, Nihei N, Naya Y and Ichikawa T: Renal cell carcinoma with a huge solitary metastasis to the contralateral adrenal gland: A case report. Int J Urol. 15:1077–1079. 2008. View Article : Google Scholar : PubMed/NCBI
19	Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI
20	Coppin C, Kollmannsberger C, Le L, Porzsolt F and Wilt TJ: Targeted therapy for advanced renal cell cancer (RCC): A Cochrane systematic review of published randomised trials. BJU Int. 108:1556–1563. 2011. View Article : Google Scholar : PubMed/NCBI