Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Dong,Zhe-Yi; Xing,Hai-Tao; Wang,Yuan-Da; Zhang,Wei; Qiu,Qiang; Chen,Xiang-Mei

doi:10.3892/ol.2015.3669

Multiple myeloma with a previous diagnosis of focal segmental glomerulosclerosis: A case report and review of the literature

Authors:
- Zhe-Yi Dong
- Hai-Tao Xing
- Yuan-Da Wang
- Wei Zhang
- Qiang Qiu
- Xiang-Mei Chen
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Affiliations: Department of Nephrology, State Key Laboratory of Kidney Disease, National Clinical Research Center for Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
Published online on: September 3, 2015 https://doi.org/10.3892/ol.2015.3669
Pages: 2821-2827
Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The presentation of focal segmental glomerulosclerosis (FSGS) and multiple myeloma (MM), either together or in succession, is extremely rare. Only nine studies have previously reported this poorly understood association. The present study reports the case of a 45-year-old male with FSGS that was diagnosed by a renal biopsy performed for nephrotic syndrome (NS). The patient was admitted to the Chinese People's Liberation Army General Hospital one year later with a fever, anemia, unresolved NS and renal insufficiency. The patient was diagnosed with MM and a renal biopsy was repeated, the results of which suggested renal amyloidosis. The MM was treated with three cycles of vincristine, doxorubicin and dexamethasone chemotherapy. A review of the literature indicated that monoclonal gammopathy may lead to FSGS. It suggested that FSGS patients who are >40 years old should be routinely screened for plasma cell proliferative disorders to guide the treatment, determine a prognosis, achieve primary disease remission and avoid end‑stage renal disease.

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