Role of radiotherapy in the treatment of primary mediastinal large B‑cell lymphoma

  • Authors:
    • Jingjing Wang
    • Xianling Liu
    • Fang Ma
    • Ming Huang
    • Yashpal Singh Kallychurn
    • Chunhong Hu
  • View Affiliations

  • Published online on: September 15, 2015     https://doi.org/10.3892/ol.2015.3700
  • Pages: 2925-2930
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Abstract

The role of radiotherapy (RT) in the treatment of primary mediastinal large B‑cell lymphoma (PMLBCL) is unclear. In the present study, a retrospective analysis of 63 patients with PMLBCL treated with or without RT was performed to evaluate the role of RT. Clinical outcomes were calculated using the Kaplan‑Meier method and were compared between patients who did and did not receive RT, using the log‑rank test. A multivariate analysis was performed using Cox proportional hazards model. After chemotherapy, 35 patients received RT, and RT was found to be associated with significantly improved 5‑year overall survival (OS) (87 vs. 58%; P=0.001) and 5‑year progression‑free survival (PFS) (75 vs. 39%; P=0.001) rates compared with patients without RT. The subgroup analysis on 35 patients who received rituximab plus chemotherapy showed that RT did not improve the 5‑year OS (88 vs. 92%; P=0.814) or the 5‑year PFS (78 vs. 65%; P=0.511) rates compared with patients without RT. On multivariate analysis, RT and the addition of rituximab were predictive of increased OS [RT: Hazard ratio (HR), 0.157; P=0.018; rituximab: HR, 0.156; P=0.009] and PFS (RT: HR 0.111, P=0.001; Rituximab: HR 0.231, P=0.002) rates. However, the role of RT in PMLBCL in the rituximab era is unclear. Further investigation of the role of RT in the era of targeted therapy is required.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang J, Liu X, Ma F, Huang M, Kallychurn YS and Hu C: Role of radiotherapy in the treatment of primary mediastinal large B‑cell lymphoma. Oncol Lett 10: 2925-2930, 2015
APA
Wang, J., Liu, X., Ma, F., Huang, M., Kallychurn, Y.S., & Hu, C. (2015). Role of radiotherapy in the treatment of primary mediastinal large B‑cell lymphoma. Oncology Letters, 10, 2925-2930. https://doi.org/10.3892/ol.2015.3700
MLA
Wang, J., Liu, X., Ma, F., Huang, M., Kallychurn, Y. S., Hu, C."Role of radiotherapy in the treatment of primary mediastinal large B‑cell lymphoma". Oncology Letters 10.5 (2015): 2925-2930.
Chicago
Wang, J., Liu, X., Ma, F., Huang, M., Kallychurn, Y. S., Hu, C."Role of radiotherapy in the treatment of primary mediastinal large B‑cell lymphoma". Oncology Letters 10, no. 5 (2015): 2925-2930. https://doi.org/10.3892/ol.2015.3700