Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study

Li,Peijing; Hu,Weihan; Zhu,Yuan; Liu,Jianjiang

doi:10.3892/ol.2015.3640

Treatment and predictive factors in patients with recurrent laryngeal carcinoma: A retrospective study

Authors:
- Peijing Li
- Weihan Hu
- Yuan Zhu
- Jianjiang Liu
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Affiliations: Sun Yat‑Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China
Published online on: August 25, 2015 https://doi.org/10.3892/ol.2015.3640
Pages: 3145-3152

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Abstract

The aim of the present retrospective analysis was to evaluate the treatment results for recurrent laryngeal cancer and to analyze the factors that may affect survival. A retrospective review was performed in 309 patients with recurrent laryngeal carcinoma, 224 of whom were treated between 1996 and 2009 at Sun Yat‑Sen University Cancer Center (Guangzhou, Guangdong, China) and 85 of whom were treated between 2006 and 2013 at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China). The Kaplan‑Meier method with the log‑rank computation was used for the analysis of survival. The Cox proportional hazards model was applied to identify covariates that were significantly associated with overall survival. The actuarial 3‑, 5‑ and 10‑year survival rates were 68.9, 53.6 and 35.7%, respectively. Univariate analysis indicated that the following factors were associated with survival: Age, smoking index, tumor grade, primary tumor site, nodal status of the primary tumor, initial T stage, initial Union for International Cancer Control stage, initial treatment (radiotherapy or chemotherapy), disease‑free interval, eligibility for surgery and extent of recurrence. Multivariate analysis of these factors indicated that the initial T stage, tumor grade, nodal status, disease‑free interval and eligibility for surgery were significantly associated with survival. Overall, these results indicate that initial tumor stage T1 or T2, a high differentiation rate, no initial cervical lymph node metastasis, a long disease‑free interval and a strong indication for salvage surgery are good prognostic factors for the survival of patients with recurrent laryngeal carcinoma.

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1	Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet. 371:1695–1709. 2008. View Article : Google Scholar : PubMed/NCBI
2	Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI
3	Barthel SW and Esclamado RM: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124:35–39. 2001. View Article : Google Scholar : PubMed/NCBI
4	Answer. Yuen AP, Ho CM, Wei WI and Lam LK: Analysis of recurrence after surgical treatment of advanced laryngeal carcinoma. J Laryngol Otol. 109:1063–1067. 1995.PubMed/NCBI
5	Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The department of veterans affairs laryngeal cancer study group. N Engl J Med. 324:1685–1690. 1991. View Article : Google Scholar : PubMed/NCBI
6	Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L and Sahmoud T: Larynx preservation in pyriform sinus cancer: Preliminary results of a European organization for research and treatment of cancer phase III trial. EORTC head and neck cancer cooperative group. J Natl Cancer Inst. 88:890–899. 1996. View Article : Google Scholar : PubMed/NCBI
7	Hanna EY: Subglottic cancer. Am J Otolaryngol. 15:322–328. 1994. View Article : Google Scholar : PubMed/NCBI
8	Strome SE, Robey TC, Devaney KO, Krause CJ and Hogikyan ND: Subglottic carcinoma: Review of a series and characterization of its patterns of spread. Ear Nose Throat J. 78:622–624. 1999.PubMed/NCBI
9	Marshak G, Brenner B, Shvero J, Shapira J, Ophir D, Hochman I, Marshak G, Sulkes A and Rakowsky E: Prognostic factors for local control of early glottic cancer: The Rabin medical center retrospective study on 207 patients. Int J Radiat Oncol Biol Phys. 43:1009–1013. 1999. View Article : Google Scholar : PubMed/NCBI
10	Rübe C, Micke O, Grevers G, Rohloff R, Kaufmann H, Busch M and Willich N: Primary radiotherapy of laryngeal carcinoma. An analysis of the therapeutic results and of the relapse behavior in 283 patients. Strahlenther Onkol. 173:83–90. 1997.(In German). View Article : Google Scholar : PubMed/NCBI
11	Agra IM, Ferlito A, Takes RP, Silver CE, Olsen KD, Stoeckli SJ, Strojan P, Rodrigo JP, Filho J Gonçalves, Genden EM, et al: Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. Head & Neck. 34:727–735. 2012. View Article : Google Scholar
12	Yuen AP, Wei WI, Hui Y and Ho WK: Comprehensive analysis of pharyngeal recurrence of laryngeal carcinoma after total laryngectomy. Am J Otolaryngol. 17:380–385. 1996. View Article : Google Scholar : PubMed/NCBI
13	Brenner B, Marshak G, Sulkes A and Rakowsky E: Prognosis of patients with recurrent laryngeal carcinoma. Head Neck. 23:531–535. 2001. View Article : Google Scholar : PubMed/NCBI
14	Soo KC, Shah JP, Gopinath KS, Gerold FP, Jaques DP and Strong EW: Analysis of prognostic variables and results after supraglottic partial laryngectomy. Am J Surg. 156:301–305. 1988. View Article : Google Scholar : PubMed/NCBI
15	Bocca E, Pignataro O and Oldini C: Supraglottic laryngectomy: 30 years of experience. Ann Otol Rhinol Laryngol. 92:14–18. 1983. View Article : Google Scholar : PubMed/NCBI
16	Mittal B, Marks JE and Ogura JH: Transglottic carcinoma. Cancer. 53:151–161. 1984. View Article : Google Scholar : PubMed/NCBI
17	Davidson J, Keane T, Brown D, Freeman J, Gullane P, Irish J, Rotstein L, Pintilie M and Cummings B: Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 123:420–424. 1997. View Article : Google Scholar : PubMed/NCBI
18	Green FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG and Morrow M: American Joint Committee on Cancer: AJCC Cancer Staging Manual (6th). Springer-Verlag. New York, NY: 61–71. 2002.
19	Arnold DJ, Goodwin WJ, Weed DT and Civantos FJ: Treatment of recurrent and advanced stage squamous cell carcinoma of the head and neck. Semin Radiat Oncol. 14:190–195. 2004. View Article : Google Scholar : PubMed/NCBI
20	Lacy PD and Piccirillo JF: Development of a new staging system for patients with recurrent laryngeal squamous cell carcinoma. Cancer. 83:910–917. 1998. View Article : Google Scholar : PubMed/NCBI
21	Mallis A, Jelastopulu E, Mastronikolis NS, Naxakis SS, Kourousis C and Papadas TA: Laryngeal cancer and passive smoking: the neglected factor? Eur Arch Otorhinolaryngol. 268:727–731. 2011. View Article : Google Scholar : PubMed/NCBI