Open Access

Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma

  • Authors:
    • Hui Zhang
    • Qiufen Guo
    • Xia Wang
    • Chong Wang
    • Xingbo Zhao
    • Mingjiang Li
  • View Affiliations

  • Published online on: October 27, 2015     https://doi.org/10.3892/ol.2015.3835
  • Pages: 45-50
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fibroblast growth factor (FGF) 2-mediated signaling of the mitogen-activated protein kinase/RAS/extracellular signal-regulated kinase 1/2 pathway is a critical modulator in angiogenesis and is therefore essential for the pathogenesis of endometrial carcinoma. Human similar expression to FGFs (hSef) and Sprouty4 have each been reported to be negative regulators of FGF signaling. The aim of the present study was to investigate the expression of hSef and Sprouty4 in human endometrial adenocarcinoma. Using immunohistochemistry analysis, the expression of hSef and Sprouty4 was detected in human endometrial adenocarcinomas. Increased hSef expression was found to be present in endometrial adenocarcinomas. In addition, decreased hSef expression was identified in the blood vessels of endometrial adenocarcinoma samples. However, the expression of Sprouty4 was downregulated in human endometrial adenocarcinoma. Aberrant expression of hSef and Sprouty4 are involved in the pathogenesis of human endometrial adenocarcinoma.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Guo Q, Wang X, Wang C, Zhao X and Li M: Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma. Oncol Lett 11: 45-50, 2016
APA
Zhang, H., Guo, Q., Wang, X., Wang, C., Zhao, X., & Li, M. (2016). Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma. Oncology Letters, 11, 45-50. https://doi.org/10.3892/ol.2015.3835
MLA
Zhang, H., Guo, Q., Wang, X., Wang, C., Zhao, X., Li, M."Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma". Oncology Letters 11.1 (2016): 45-50.
Chicago
Zhang, H., Guo, Q., Wang, X., Wang, C., Zhao, X., Li, M."Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma". Oncology Letters 11, no. 1 (2016): 45-50. https://doi.org/10.3892/ol.2015.3835