Epidermal inclusion cyst of the breast: A literature review

Paliotta,Annalisa; Sapienza,Paolo; D'Ermo,Giuseppe; Cerone,Gennaro; Pedullà,Giuseppe; Crocetti,Daniele; De Gori,Antonietta; De Toma,Giorgio

doi:10.3892/ol.2015.3968

Epidermal inclusion cyst of the breast: A literature review

Authors:
- Annalisa Paliotta
- Paolo Sapienza
- Giuseppe D'Ermo
- Gennaro Cerone
- Giuseppe Pedullà
- Daniele Crocetti
- Antonietta De Gori
- Giorgio De Toma
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Affiliations: Department of Surgery ῾Pietro Valdoni᾽, Policlinico Umberto I, ῾Sapienza᾽ University of Rome, Rome 00161, Italy
Published online on: November 24, 2015 https://doi.org/10.3892/ol.2015.3968
Pages: 657-660

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Abstract

An epidermal inclusion cyst (EIC) of the breast is a rare, benign condition that may potentially be malignant. The present study conducted a systematic review of the literature in order to identify pathological hypotheses, clinical characteristics, and diagnostic and treatment options. A search for relevant studies was conducted through the Scopus, Embase and Medline databases during September 2014. The search term employed was ῾epidermal inclusion cyst breast᾽. Studies were selected if they contained adequate information regarding symptoms at presentation, diagnostic tools, pathology, characteristics, type of procedure performed and follow‑up routines. A total of 35 papers describing 91 patients affected by EIC of the breast were identified. Following this, a total of 82 patients, including an additional case supplied from the present study, were selected for further analysis. EIC of the breast typically occurs during the fifth decade of life. A palpable mass of the breast was present in 65 (79%) patients. Ultrasonographic imaging was consistently utilized as a diagnostic tool in all the cases analyzed, whereas fine‑needle aspiration cytology was used in 70% of the cases and mammography in 65%. No tumor recurrence was reported at a mean follow‑up time of 53 months. The present study demonstrated that elliptical excision is the preferred treatment for EIC of the breast, with pathological analysis required to exclude malignancy.

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