Prognostic implications of survivin and lung resistance protein in advanced non-small cell lung cancer treated with platinum-based chemotherapy

  • Authors:
    • Wenfeng Huang
    • Yan Mao
    • Yongzi Zhan
    • Jianfeng Huang
    • Xiangping Wang
    • Penghui Luo
    • Li Li
    • Dunchang Mo
    • Qiong Liu
    • Huimin Xu
    • Changjie Huang
  • View Affiliations

  • Published online on: November 13, 2015     https://doi.org/10.3892/ol.2015.3913
  • Pages: 723-730
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Abstract

Platinum-based chemotherapy is the first-line treatment for non-small cell lung cancer (NSCLC), but the chemotherapy often results in the development of chemoresistance. The present study aimed to explore the prognostic implications of survivin and lung resistance protein (LRP) in advanced NSCLC treated with platinum‑based chemotherapy. Tumor samples were collected from 61 hospitalized patients with stage IIIB‑IV NSCLC that underwent platinum‑based chemotherapy. All patient samples were collected in the Oncology Department of the Third Affiliated Hospital of Guangxi Medical University between January 2006 and January 2011. Cytoplasmic survivin and LRP expression were evaluated using immunohistochemistry. The expression of LRP and survivin reached 77% (47/61) and 76% (45/61), respectively. Positive expression of survivin was associated with a lower median progression‑free survival (PFS) time (4 vs. 9 months; P=0.038) and a lower median overall survival (OS) time compared with the absence of survivin expression (9 vs. 16 months; P=0.039). Patients with LRP and survivin expression (n=41) demonstrated a median PFS time of 4 months. However, patients with either LRP or survivin expression (n=10) demonstrated a median PFS time of 8 months, which is similar to the median PFS time of the 10 patients with no expression of LRP and survivin (9 months; P=0.022). Either the expression of survivin or the combined expression of LRP and survivin is associated with a poor prognosis in advanced NSCLC treated with platinum-based chemotherapy.
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January-2016
Volume 11 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Huang W, Mao Y, Zhan Y, Huang J, Wang X, Luo P, Li L, Mo D, Liu Q, Xu H, Xu H, et al: Prognostic implications of survivin and lung resistance protein in advanced non-small cell lung cancer treated with platinum-based chemotherapy. Oncol Lett 11: 723-730, 2016
APA
Huang, W., Mao, Y., Zhan, Y., Huang, J., Wang, X., Luo, P. ... Huang, C. (2016). Prognostic implications of survivin and lung resistance protein in advanced non-small cell lung cancer treated with platinum-based chemotherapy. Oncology Letters, 11, 723-730. https://doi.org/10.3892/ol.2015.3913
MLA
Huang, W., Mao, Y., Zhan, Y., Huang, J., Wang, X., Luo, P., Li, L., Mo, D., Liu, Q., Xu, H., Huang, C."Prognostic implications of survivin and lung resistance protein in advanced non-small cell lung cancer treated with platinum-based chemotherapy". Oncology Letters 11.1 (2016): 723-730.
Chicago
Huang, W., Mao, Y., Zhan, Y., Huang, J., Wang, X., Luo, P., Li, L., Mo, D., Liu, Q., Xu, H., Huang, C."Prognostic implications of survivin and lung resistance protein in advanced non-small cell lung cancer treated with platinum-based chemotherapy". Oncology Letters 11, no. 1 (2016): 723-730. https://doi.org/10.3892/ol.2015.3913