Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report

Yu,Xiaolong; Guo,Runsheng; Fan,Congliang; Liu,Hucheng; Zhang,Bin; Nie,Tao; Tu,Yi; Dai,Min

doi:10.3892/ol.2016.4080

Aneurysmal bone cyst secondary to a giant cell tumor of the patella: A case report

Authors:
- Xiaolong Yu
- Runsheng Guo
- Congliang Fan
- Hucheng Liu
- Bin Zhang
- Tao Nie
- Yi Tu
- Min Dai
View Affiliations

Affiliations: Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi 330006, P.R. China, Multidisciplinary Therapy Center of Musculoskeletal Tumor, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Pathology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Published online on: January 7, 2016 https://doi.org/10.3892/ol.2016.4080
Pages: 1481-1485

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The patella is an unusual location for primary and metastatic bone tumors to develop. The most frequently encountered primary osteolytic lesions at the patella include giant cell tumors of the bone (GCT), chondroblastoma and aneurysmal bone cysts (ABC). However, the presentation of an ABC originating secondary to a GCT at the patella is rare. The present study describes such a case in a 46‑year‑old female. The differential diagnosis of the condition was extensive. The patient underwent curettage and the addition of bone cement to fill the defect. Pathological analysis of the resected tissue demonstrated that the lesion was consistent with an ABC forming secondary to a GCT. A 3‑month follow‑up was completed subsequent to the surgery, with a computed tomography scan demonstrating no evidence of recurrence. However, frequent and continuous observations of the patient following diagnosis are planned in order to evaluate the long‑term efficacy of the surgical treatment. To the best of our knowledge, the present study describes the third reported case in the literature of this rare, double synchronous, benign tumor located at the patella.

View Figures

View References

1	van der Heijden L, Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, Bovée JV, Hogendoorn PC and Gelderblom P: The clinical approach toward giant cell tumor of bone. Oncologist. 19:550–561. 2014. View Article : Google Scholar : PubMed/NCBI
2	Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT and Kransdorf MJ: From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologic-pathologic correlation. Radiographics. 21:1283–1309. 2001. View Article : Google Scholar : PubMed/NCBI
3	Salunke P, Futane S and Jain V: Aneurysmal bone cyst of cervical spine: True 360° resection with emphasis on lateral masses. Neurol India. 60:113–115. 2012. View Article : Google Scholar : PubMed/NCBI
4	Jaffe HL and Lichtenstein L: Solitary unicameral bone cyst with emphasis on the roentgen picture, the pathologic appearance and the pathogenesis. Arch Surg. 44:1004–1025. 1942. View Article : Google Scholar
5	Oh JH, Kim HH, Gong HS, Lee SL, Kim JY and Kim WS: Primary aneurysmal bone cyst of the patella: A case report. J Orthop Surg (Hong Kong). 15:234–237. 2007.PubMed/NCBI
6	Cottalorda J and Bourelle S: Modern concepts of primary aneurysmal bone cyst. Arch Orthop Trauma Surg. 127:105–114. 2007. View Article : Google Scholar : PubMed/NCBI
7	Singh J, James SL, Kroon HM, Woertler K, Anderson SE, Jundt G and Davies AM: Tumour and tumour-like lesions of the patella - a multicentre experience. Eur Radiol. 19:701–712. 2009. View Article : Google Scholar : PubMed/NCBI
8	Mercuri M and Casadei R: Patellar tumors. Clin Orthop Relat Res. 389:35–46. 2001. View Article : Google Scholar : PubMed/NCBI
9	Saglik Y, Yildiz Y, Basarir K, Tezen E and Güner D: Tumours and tumour-like lesions of the patella: A report of eight cases. Acta Orthop Belg. 74:391–396. 2008.PubMed/NCBI
10	Macdonald D, Fornasier V and Cameron J: Multicentric giant cell tumour involving the patella. Can J Surg. 44:222–223. 2001.PubMed/NCBI
11	Chakarun CJ, Forrester DM, Gottsegen CJ, Patel DB, White EA and Matcuk GR Jr: Giant cell tumor of bone: Review, mimics, and new developments in treatment. Radiographics. 33:197–211. 2013. View Article : Google Scholar : PubMed/NCBI
12	Campanacci M, Baldini N, Boriani S and Sudanese A: Giant-cell tumor of bone. J Bone Joint Surg Am. 69:106–114. 1987.PubMed/NCBI
13	Nahal A, Ajlan A, Alcindor T and Turcotte R: Dedifferentiated giant cell tumour of bone in the form of low-grade fibroblastic osteogenic sarcoma: Case report of a unique presentation with follow-up. Curr Oncol. 17:71–76. 2010. View Article : Google Scholar : PubMed/NCBI
14	Mooren JJ, Theunissen PH and Zijlker TD: Pathology quiz case 2: Laryngeal giant cell tumor (LGCT). JAMA Otolaryngol Head Neck Surg. 139:89–90. 2013. View Article : Google Scholar : PubMed/NCBI
15	Murphey MD, Nomikos GC, Flemming DJ, Gannon FH, Temple HT and Kransdorf MJ: From the archives of AFIP. Imaging of giant cell tumor and giant cell reparative granuloma of bone: Radiologic-pathologic correlation. Radiographics. 21:1283–1309. 2001. View Article : Google Scholar : PubMed/NCBI
16	Lee MJ, Sallomi DF, Munk PL, Janzen DL, Connell DG, O'Connell JX, Logan PM and Masri BA: Pictorial review: Giant cell tumours of bone. Clin Radiol. 53:481–489. 1998. View Article : Google Scholar : PubMed/NCBI
17	Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, Pignotti E, Biagini R and Schwab JH: Giant cell tumor of the mobile spine: A review of 49 cases. Spine (Phila Pa 1976). 37:E37–E45. 2012. View Article : Google Scholar : PubMed/NCBI
18	Mankin HJ, Hornicek FJ, Ortiz-Cruz E, Villafuerte J and Gebhardt MC: Aneurysmal bone cyst: A review of 150 patients. J Clin Oncol. 23:6756–6762. 2005. View Article : Google Scholar : PubMed/NCBI
19	Wu Z, Yang X, Xiao J, Feng D, Huang Q, Zheng W, Huang W and Zhou Z: Aneurysmal bone cyst secondary to giant cell tumor of the mobile spine: A report of 11 cases. Spine (Phila Pa 1976). 36:E1385–E1390. 2011. View Article : Google Scholar : PubMed/NCBI
20	Saccomanni B: Aneurysmal bone cyst of spine: A review of literature. Arch Orthop Trauma Surg. 128:1145–1147. 2008. View Article : Google Scholar : PubMed/NCBI
21	Panoutsakopoulos G, Pandis N, Kyriazoglou I, Gustafson P, Mertens F and Mandahl N: Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. Genes Chromosomes Cancer. 26:265–266. 1999. View Article : Google Scholar : PubMed/NCBI
22	Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N, Bridge JA, Perez-Atayde AR and Fletcher P: USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. Cancer Res. 64:1920–1923. 2004. View Article : Google Scholar : PubMed/NCBI
23	Kenney B, Richkind KE and Zambrano E: Solid variant of aneurysmal bone cyst with a novel (X;9) translocation. Cancer Genet Cytogenet. 178:155–159. 2007. View Article : Google Scholar : PubMed/NCBI
24	Baruffi MR, Neto JB, Barbieri CH and Casartelli C: Aneurysmal bone cyst with chromosomal changes involving 7q and 16p. Cancer Genet Cytogenet. 129:177–180. 2001. View Article : Google Scholar : PubMed/NCBI
25	Hao Y, Wang L, Yan M, Jin F, Ge S and Dai K: Soft tissue aneurysmal bone cyst in a 10-year-old girl. Oncol Lett. 3:545–548. 2012.PubMed/NCBI
26	Mahnken AH, Nolte-Ernsting CC, Wildberger JE, Heussen N, Adam G, Wirtz DC, Piroth W, Bücker A, Biesterfeld S, Haage P and Günther RW: Aneurysmal bone cyst: Value of MR imaging and conventional radiography. Eur Radiol. 13:1118–1124. 2003.PubMed/NCBI
27	Roemer FW, Remplik P and Bohndorf K: Uncommon aneurysmal bone cyst: Radiographic and MRI findings. AJR Am J Roentgenol. 184:3492005. View Article : Google Scholar : PubMed/NCBI
28	Lin SP, Fang YC, Chu DC, Chang YC and Hsu CI: Characteristics of cranial aneurysmal bone cyst on computed tomography and magnetic resonance imaging. J Formos Med Assoc. 106:255–259. 2007. View Article : Google Scholar : PubMed/NCBI
29	Yang BT, Wang YZ, Wang XY and Wang ZC: Imaging study of ossifying fibroma with associated aneurysmal bone cyst in the paranasal sinus. Eur J Radiol. 81:3450–3455. 2012. View Article : Google Scholar : PubMed/NCBI
30	Benamou J, Lussier B, Alexander K, Gains MJ and Savard C: Use of magnetic resonance imaging and histopathologic findings for diagnosis of an aneurysmal bone cyst in the scapula of a cat. J Am Vet Med Assoc. 240:69–74. 2012. View Article : Google Scholar : PubMed/NCBI
31	Hong WS, Sung MS, Kim JH, Kim HM, Kim TK, Chung MH, Lim YS and Lim HW: Giant cell tumor with secondary aneurysmal bone cyst: A unique presentation with an ossified extraosseous soft tissue mass. Skeletal Radiol. 42:1605–1610. 2013. View Article : Google Scholar : PubMed/NCBI