Open Access

Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor

  • Authors:
    • Hana Študentová
    • Jarmila Indráková
    • Pavla Petrová
    • Milan Kamínek
    • Hana Kalábová
    • Vlastislav Šrámek
    • Tomáš Adam
    • Bohuslav Melichar
  • View Affiliations

  • Published online on: December 9, 2015     https://doi.org/10.3892/ol.2015.4017
  • Pages: 939-944
  • Copyright: © Študentová et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to examine the changes in intima‑media thickness (IMT) and myocardial perfusion in association with other laboratory risk factors for atherosclerosis in patients treated with therapy that targeted vascular endothelial growth factor (VEGF). IMT, myocardial perfusion and laboratory risk factors of atherosclerosis were studied in 58 patients with metastatic colorectal carcinoma or metastatic renal cell carcinoma prior to and at 3‑monthly intervals during anti‑VEGF treatment. Compared with the pretreatment IMT, the results indicated that the IMT was consistently increased during therapy in the two patient groups. Patient blood pressure and concentration of troponin T increased transiently. An increase in the concentration of high‑density lipoprotein cholesterol and decrease in the concentrations of C‑reactive protein and homocysteine were also observed. Novel myocardial ischemia was evident in individual patients. In conclusion, anti‑VEGF therapy affects the laboratory risk factors of atherosclerosis and results in an acceleration of atherosclerosis, as demonstrated by increased IMT.
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February-2016
Volume 11 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Študentová H, Indráková J, Petrová P, Kamínek M, Kalábová H, Šrámek V, Adam T and Melichar B: Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncol Lett 11: 939-944, 2016
APA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V. ... Melichar, B. (2016). Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor. Oncology Letters, 11, 939-944. https://doi.org/10.3892/ol.2015.4017
MLA
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11.2 (2016): 939-944.
Chicago
Študentová, H., Indráková, J., Petrová, P., Kamínek, M., Kalábová, H., Šrámek, V., Adam, T., Melichar, B."Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor". Oncology Letters 11, no. 2 (2016): 939-944. https://doi.org/10.3892/ol.2015.4017