Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization

  • Authors:
    • Xi Zhou
    • Yongli Chen
    • Yongmei Li
    • Zhao Duan
  • View Affiliations

  • Published online on: December 28, 2011     https://doi.org/10.3892/ol.2011.542
  • Pages: 659-661
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Abstract

In the present study, the case of a 34-year-old Chinese female who underwent in vitro fertilization resulting in a twin pregnancy was reported. Following in vitro fertilization, the patient was found to have a partial hydatidiform mole (PHM) with a co-existing twin by transvaginal sonography (TVS). At 16 weeks, the pregnancy was terminated and a normal-looking fetus with a HM placenta was delivered, in addition to a normal fetus with a normal placenta. Following termination of the pregnancy, the PHM progressed into an invasive mole with lung metastasis, a rare event. Serum human chorionic gonadotrophin (hCG) concentrations decreased in the first week following delivery, but over the following 21 days hCG levels showed a continuous increase. Following 2 cycles of combinative chemotherapy consisting of fluorouracil (5-FU) and dactinomycin (KSM), hCG concentrations decreased to normal levels. The patient was then administered 1 cycle of repeated chemotherapy and hCG levels remained negative for the following 2 years.
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March 2012
Volume 3 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou X, Chen Y, Li Y and Duan Z: Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. Oncol Lett 3: 659-661, 2012
APA
Zhou, X., Chen, Y., Li, Y., & Duan, Z. (2012). Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization. Oncology Letters, 3, 659-661. https://doi.org/10.3892/ol.2011.542
MLA
Zhou, X., Chen, Y., Li, Y., Duan, Z."Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization". Oncology Letters 3.3 (2012): 659-661.
Chicago
Zhou, X., Chen, Y., Li, Y., Duan, Z."Partial hydatidiform mole progression into invasive mole with lung metastasis following in vitro fertilization". Oncology Letters 3, no. 3 (2012): 659-661. https://doi.org/10.3892/ol.2011.542