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Article

Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia

  • Authors:
    • Grazia Palomba
    • Mario Budroni
    • Nina Olmeo
    • Francesco Atzori
    • Maria Teresa Ionta
    • Marina Pisano
    • Francesco Tanda
    • Antonio Cossu
    • Giuseppe Palmieri
  • View Affiliations / Copyright

    Affiliations: Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Sassari, Sassari, Italy, Service of Epidemiology, Local Health Unit 1 (ASL1), Sassari, Sassari, Italy, Unit of Medical Oncology, Local Health Unit 1 (ASL1), Sassari, Sassari, Italy, Department of Medical Oncology, Hospital‑University Health Unit (AOU), Cagliari, Cagliari, Italy, Institute of Pathology, University of Sassari, Sassari, Sassari, Italy, Service of Pathology, Hospital‑University Health Unit (AOU), Sassari, Sassari, Italy
  • Pages: 948-952
    |
    Published online on: January 28, 2014
       https://doi.org/10.3892/ol.2014.1834
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Abstract

Germline mutations in BRCA1 or BRCA2 genes have been demonstrated to increase the risk of developing breast cancer. Among the prognostic factors currently used in clinical practice, the disease stage and the receptor status play a crucial role in the management of breast carcinoma. Triple‑negative breast cancer (TNBC) has been classified as a disease subgroup that is negative for oestrogen, progesterone and HER2 receptor expression, and presents a poor prognosis. The present study investigated the correlation between BRCA1/2 mutations and TNBC status in a large series (n=726) of breast cancer patients from Sardinia. The BRCA mutation screening was performed on genomic DNA from peripheral blood samples by denaturing high‑performance liquid chromatography analysis and automated DNA sequencing. Overall, 21/726 (2.9%) patients carried a germline mutation in BRCA1 or BRCA2. The TNBC phenotype was significantly associated with the BRCA1 mutations (P<0.001), whereas no association was found with the BRCA2 mutations (P=0.837). With respect to patient origin within Sardinia, a significant inverse distribution of mutations was found; BRCA1 and BRCA2 mutations represented 86 and 93% of the mutated cases in Southern and Middle‑Northern Sardinia, respectively (P<0.001). Patients from the geographical area with BRCA1 mutation prevalence presented a TNBC incidence much higher than that observed in cases from the area with BRCA2 mutation prevalence (12 vs. 4%, respectively; P=0.037). These findings further confirmed that the occurrence of TNBC is significantly associated with the BRCA1 mutation carrier status and that a different ‘genetic background’ may have a phenotypic impact in the onset of breast cancer.
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1 

Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Richardson AL, Schnitt SJ, Schmitt FC, Tan PH, Tse GM, Badve S and Ellis IO: Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 12:2072010.

2 

Fuksa L, Micuda S, Grim J, Ryska A and Hornychova H: Predictive biomarkers in breast cancer: their value in neoadjuvant chemotherapy. Cancer Invest. 30:663–678. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Thibault C, Khodari W, Lequoy M, Gligorov J and Belkacémi Y: HER2 status for prognosis and prediction of treatment efficacy in adenocarcinomas: A review. Crit Rev Oncol Hematol. 88:123–133. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Foulkes WD, Smith IE and Reis-Filho JS: Triple-negative breast cancer. N Engl J Med. 363:1938–1948. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Metzger-Filho O, Tutt A, de Azambuja E, Saini KS, Viale G, Loi S, Bradbury I, Bliss JM, Azim HA Jr, Ellis P, Di Leo A, Baselga J, Sotiriou C and Piccart-Gebhart M: Dissecting the heterogeneity of triple-negative breast cancer. J Clin Oncol. 30:1879–1887. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, Bishop DT, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare MD, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck TR, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Ponder BA, Gayther SA, Zelada-Hedman M, et al: Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium. Am J Hum Genet. 62:676–689. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Dent R and Warner E: Screening for hereditary breast cancer. Semin Oncol. 34:392–400. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Meads C, Ahmed I and Riley RD: A systematic review of breast cancer incidence risk prediction models with meta-analysis of their performance. Breast Cancer Res Treat. 132:365–377. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Peshkin BN, Alabek ML and Isaacs C: BRCA1/2 mutations and triple negative breast cancers. Breast Dis. 32:25–33. 2010.PubMed/NCBI

10 

Meyer P, Landgraf K, Högel B, Eiermann W and Ataseven B: BRCA2 mutations and triple-negative breast cancer. PLoS One. 7:e383612012. View Article : Google Scholar : PubMed/NCBI

11 

Budroni M, Cesaraccio R, Pirino D, Sechi O, Oggiano M, Piras D, Sechi A, Cossu A, Palmieri G and Tanda F: Cancer incidence in Sassari Province (1998–2002). Cancer Incidence in Five Continents. IXCurado MP, Edwards B, Shin HR, Storm H, Ferlay J, Heanue M and Boyle P: (International Agency for Research on Cancer (IARC) Scientific Publications). (160)Lyon: IARC; pp. 331–332. 2007

12 

Palomba G, Pisano M, Cossu A, Budroni M, Dedola MF, Farris A, Contu A, Baldinu P, Tanda F and Palmieri G: Spectrum and prevalence of BRCA1 and BRCA2 germline mutations in Sardinian breast cancer patients through a hospital-based screening. Cancer. 104:1172–1179. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Palomba G, Cossu A, Friedman E, Budroni M, Farris A, Contu A, Pisano M, Baldinu P, Sini MC, Tanda F and Palmieri G: Origin and distribution of the BRCA2-8765delAG mutation in breast cancer. BMC Cancer. 7:1322007. View Article : Google Scholar : PubMed/NCBI

14 

Palomba G, Loi A, Uras A, Fancello P, Piras G, Gabbas A, Cossu A, Budroni M, Contu A, Tanda F, Farris A, Orrù S, Floris C, Pisano M, Lovicu M, Santona MC, Landriscina G, Crisponi L, Palmieri G and Monne M: A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population. BMC Cancer. 9:2452009. View Article : Google Scholar : PubMed/NCBI

15 

Wright AF, Carothers AD and Pirastu M: Population choice in mapping genes for complex diseases. Nat Genet. 23:397–404. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Arcos-Burgos M and Muenke M: Genetics of population isolates. Clin Genet. 61:233–247. 2002. View Article : Google Scholar

17 

Mote PA, Leary JA, Avery KA, Sandelin K, Chenevix-Trench G, Kirk JA and Clarke CL; kConFab Investigators. Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A. Genes Chromosomes Cancer. 39:236–248. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Veronesi A, de Giacomi C, Magri MD, Lombardi D, Zanetti M, Scuderi C, Dolcetti R, Viel A, Crivellari D, Bidoli E and Boiocchi M: Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases. BMC Cancer. 5:702005.

19 

Musolino A, Bella MA, Bortesi B, Michiara M, Naldi N, Zanelli P, Capelletti M, Pezzuolo D, Camisa R, Savi M, Neri TM and Ardizzoni A: BRCA mutations, molecular markers, and clinical variables in early-onset breast cancer: a population-based study. Breast. 16:280–292. 2007. View Article : Google Scholar

20 

Casula M, Colombino M, Satta MP, Cossu A, Lissia A, Budroni M, Simeone E, Calemma R, Loddo C, Caracò C, Mozzillo N, Daponte A, Comella G, Canzanella S, Guida M, Castello G, Ascierto PA and Palmieri G; Italian Melanoma Intergroup. Factors predicting the occurrence of germline mutations in candidate genes among patients with cutaneous malignant melanoma from South Italy. Eur J Cancer. 43:137–143. 2007. View Article : Google Scholar

21 

Palomba G, Colombino M, Contu A, Massidda B, Baldino G, Pazzola A, Ionta MT, Capelli F, Trova V, Sedda T, Sanna G, Tanda F and Budroni M; Sardinian Translational Oncology Group (STOG). Palmieri G, Cossu A, Contu M, Cuccu A, Farris A, Macciò A, Mameli G, Olmeo N, Ortu S, Petretto E, Pusceddu V and Virdis L: Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia. J Transl Med. 10:1782012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Palomba G, Budroni M, Olmeo N, Atzori F, Ionta MT, Pisano M, Tanda F, Cossu A and Palmieri G: Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia. Oncol Lett 7: 948-952, 2014.
APA
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M.T., Pisano, M. ... Palmieri, G. (2014). Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia. Oncology Letters, 7, 948-952. https://doi.org/10.3892/ol.2014.1834
MLA
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M. T., Pisano, M., Tanda, F., Cossu, A., Palmieri, G."Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia". Oncology Letters 7.4 (2014): 948-952.
Chicago
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M. T., Pisano, M., Tanda, F., Cossu, A., Palmieri, G."Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia". Oncology Letters 7, no. 4 (2014): 948-952. https://doi.org/10.3892/ol.2014.1834
Copy and paste a formatted citation
x
Spandidos Publications style
Palomba G, Budroni M, Olmeo N, Atzori F, Ionta MT, Pisano M, Tanda F, Cossu A and Palmieri G: Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia. Oncol Lett 7: 948-952, 2014.
APA
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M.T., Pisano, M. ... Palmieri, G. (2014). Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia. Oncology Letters, 7, 948-952. https://doi.org/10.3892/ol.2014.1834
MLA
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M. T., Pisano, M., Tanda, F., Cossu, A., Palmieri, G."Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia". Oncology Letters 7.4 (2014): 948-952.
Chicago
Palomba, G., Budroni, M., Olmeo, N., Atzori, F., Ionta, M. T., Pisano, M., Tanda, F., Cossu, A., Palmieri, G."Triple‑negative breast cancer frequency and type of BRCA mutation: Clues from Sardinia". Oncology Letters 7, no. 4 (2014): 948-952. https://doi.org/10.3892/ol.2014.1834
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