Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells

Lu,Yebin; Hu,Juanjuan; Sun,Weijia; Duan,Xiaohui; Chen,Xiong

doi:10.3892/ol.2014.2607

Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells

Authors:
- Yebin Lu
- Juanjuan Hu
- Weijia Sun
- Xiaohui Duan
- Xiong Chen
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Affiliations: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
Published online on: October 10, 2014 https://doi.org/10.3892/ol.2014.2607
Pages: 2371-2378

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Abstract

The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm3, the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 µg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3‑4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain‑related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.

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